Needle biopsies on autopsy prostates: Sensitivity of cancer detection based on true prevalence
Needle biopsies on autopsy prostates: Sensitivity of cancer detection based on true prevalence
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DOI：
10.1093/jnci/djm153
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发表时间：
2007-10-03
影响因子：
10.3
通讯作者：
de la Roza, Gustavo
中科院分区：
文献类型：
--
作者：
Haas, Gabriel P.;Delongchamps, Nicolas Barry;de la Roza, Gustavo
背景这是很难估计前列腺癌活检的诊断准确性，因为阴性活检的男性不接受根治性前列腺切除术，因此没有确认的活检findings.Methods我们进行了18芯针活检尸检前列腺从164名男性谁没有前列腺癌的历史。从中外周区（MPZ）、外侧外周区（LPZ）和中央区（CZ）各采集6个芯活检组织。我们测试了年龄和肿瘤特征之间的关系，并分析了每个部位活检的敏感性。结果47例（29%）前列腺患者存在前列腺癌。在检测到的47种癌症中，根据组织学标准，20种具有临床意义。肿瘤体积与肿瘤分级（P = 0.012）和年龄（P
Background It is difficult to estimate the diagnostic accuracy of biopsy for prostate cancer because men with negative biopsy do not undergo radical prostatectomy and thus have no confirmation of biopsy findings.Methods We performed 18-core needle biopsies on autopsy prostates from 164 men who had no history of prostate cancer. Six-core biopsies were taken from each of the mid peripheral zone (MPZ), the lateral peripheral zone (LPZ), and the central zone (CZ). We tested associations between age and tumor characteristics and analyzed the sensitivity of biopsies at each site. All statistical tests were two-sided.Results Prostate cancer was present in 47 (29%) prostates. Of the 47 cancers detected, 20 were clinically significant according to histologic criteria. Tumor volume was associated with tumor grade (P =.012) and with age (P