Detection of early bladder cancer by 5-aminolevulinic acid induced porphyrin fluorescence
Detection of early bladder cancer by 5-aminolevulinic acid induced porphyrin fluorescence
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DOI：
10.1016/s0022-5347(01)66559-5
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发表时间：
1996-01-01
影响因子：
6.6
通讯作者：
Hostetter, A
中科院分区：
文献类型：
--
作者：
Kriegmair, M;Baumgartner, R;Hostetter, A
目的：我们确定是否可以通过5-aminolevulinic acid诱导的卟啉fluorescence.Materials和方法：3%5-aminolevulinic acid溶液膀胱灌注前膀胱镜检查104例患者的敏感性，以提高检测不典型增生或早期膀胱癌。5-氨基乙酰丙酸诱导的卟啉荧光由来自氪离子激光器的紫光（波长406.7nm）激发。结果：荧光膀胱镜的敏感性（96.9%）明显高于白色光膀胱镜（72.7%）（P <0.0001）。对特异性没有影响，结论：由于程序的高灵敏度，建议荧光引导活检而不是随机活检，
Purpose: We determined whether the sensitivity of detecting dysplasia or early bladder cancer can be improved by 5-aminolevulinic acid induced porphyrin fluorescence.Materials and Methods: A 3% 5-aminolevulinic acid solution was instilled intravesically before cystoscopy in 104 patients. The 5-aminolevulinic acid induced porphyrin fluorescence was excited by violet light from a krypton ion laser (wavelength 406.7 nm.).Results: The sensitivity of the fluorescence cystoscopy (96.9%) was significantly (p < 0.0001) greater than that of white light cystoscopy (72.7%). There was no impact on specificity,Conclusions: Due to the high sensitivity of the procedure fluorescence guided biopsies are recommended instead of random biopsies,