Reiterative use of the EGF receptor triggers differentiation of all cell types in the Drosophila eye
Reiterative use of the EGF receptor triggers differentiation of all cell types in the Drosophila eye
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DOI：
10.1016/s0092-8674(00)81385-9
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发表时间：
1996-11-15
期刊：
影响因子：
64.5
通讯作者：
Freeman, M
中科院分区：
文献类型：
--
作者：
Freeman, M
果蝇的眼睛对我们了解细胞分化有很大贡献。这种理解主要来自于对R7感光细胞的研究;对其他类型的感光细胞或非神经元视锥细胞或色素细胞的发育知之甚少。我已经使用果蝇表皮生长因子受体（DER）的显性负性形式来表明这种受体酪氨酸激酶（RTK）是所有这些细胞类型分化所必需的，我还表明DER足以触发它们的发育。R7中甚至需要DER，它可以取代另一个RTK Sevenless。这些结果拓宽了我们对眼睛发育的看法，包括整个小眼，并表明DER的反复激活对触发所有细胞类型的分化至关重要。
The Drosophila eye has contributed much to our knowledge of cell differentiation. This understanding has primarily come from the study of the R7 photoreceptor; much less is known about the development of the other classes of photoreceptor or the nonneuronal cone or pigment cells. I have used a dominant-negative form of the Drosophila epidermal growth factor receptor (DER) to show that this receptor tyrosine kinase (RTK) is required for the differentiation of all these cell types, and I have also shown that DER is sufficient to trigger their development. DER is even required in R7, where it can replace Sevenless, another RTK. These results broaden our view of eye development to include the whole ommatidium and suggest that reiterative activation of DER is critical for triggering the differentiation of all cell types.