Predictive Markers of Blood Cytokine and Chemokine in Recurrent Brain Infarction
Predictive Markers of Blood Cytokine and Chemokine in Recurrent Brain Infarction
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DOI：
10.1089/jir.2009.0012
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发表时间：
2009-11-01
影响因子：
2.3
通讯作者：
Nakagawa, Masanori
中科院分区：
文献类型：
--
作者：
Kuriyama, Nagato;Mizuno, Toshiki;Nakagawa, Masanori
动脉粥样硬化血栓形成和动脉粥样硬化进展过程中血管壁炎症反应的机制引起了人们的关注。我们重点关注炎症标志物在慢性复发性脑梗死中的潜在用途，并分析了炎症标志物在颅内动脉粥样硬化中的作用。研究对象为2004年至2006年期间接受治疗的两组患者：一组是梗塞复发的门诊患者（RI组），两次发生动脉粥样硬化性脑梗塞；一组是梗塞复发的门诊患者（RI组）。另一组门诊脑梗死且未复发的患者（BI组），脑梗死一次并保持>1年未复发；以及一组具有正常脑部磁共振成像（MRI）和磁共振血管造影（MRA）的对照受试者（C组）。采集各组患者的血浆样本，利用荧光微珠阵列系统同时测量17种候选炎症标志物，并将结果与头部MRA结果进行比较。 RI组患者的高敏C反应蛋白（hsCRP）和单核细胞趋化蛋白-1（MCP-1）水平显着高于C组和BI组。血清中 hsCRP 水平≥ 0.3 和 MCP-1 水平≥ 200 的受试者发生潜在复发性梗塞的相对风险分别为 1.92 和 2.98。关于炎症标志物水平与MRA结果的关系，RI组M1病灶处的hsCRP以及A1和M1病灶处的MCP-1水平显着高于BI组（P < 0.05）。总之，血液中的MCP-1水平和hsCRP可以作为复发性血栓性脑梗死的潜在预测标志物，并且可能反映促进颅内大动脉粥样硬化的炎症。
The mechanism of the inflammatory response in the vascular wall in atherothrombosis and during the progression of atherosclerosis has attracted attention. We focused on the potential usefulness of inflammatory markers in chronic recurrent brain infarction, and analyzed the role of inflammatory markers in atherosclerosis of the intracranial artery. The subjects were 2 groups of patients treated between 2004 and 2006: a group of outpatients with recurrent infarction (group RI), who developed atherothrombotic brain infarction twice; another group of outpatients with brain infarction without recurrence (group BI), who developed brain infarction once and remained free of recurrence for >1 year; and a group of control subjects with normal brain magnetic resonance imaging (MRI) and magnetic resonance angiography (MRA) (group C). Plasma samples were collected from each group of patients for the simultaneous measurement of 17 kinds of candidate inflammatory markers, using a fluorescent microbead array system, and the results were compared with head MRA findings. The levels of high-sensitivity C-reactive protein (hsCRP) and monocyte chemoattractant protein-1 (MCP-1) were significantly higher in group RI patients than in groups C and BI. Subjects with a hsCRP level >= 0.3 and a MCP-1 level >= 200 in the serum have, respectively, a 1.92 and 2.98 relative risk to have a potential recurrent infarction. Regarding the relation of inflammatory marker levels with MRA findings, group RI showed significantly higher levels of hsCRP at M1 lesions and MCP-1 at A1 and M1 lesions than group BI (P < 0.05). In conclusion, the MCP-1 level as well as hsCRP in the blood can be a potential predictive marker of recurrent thrombotic brain infarction, and may reflect inflammation that promotes intracranial large-artery atherosclerosis.