Comparison of Healthy and Dandruff Scalp Microbiome Reveals the Role of Commensals in Scalp Health.
Comparison of Healthy and Dandruff Scalp Microbiome Reveals the Role of Commensals in Scalp Health.
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DOI：
10.3389/fcimb.2018.00346
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发表时间：
2018
影响因子：
5.7
通讯作者：
Sharma VK
中科院分区：
文献类型：
--
作者：
Saxena R;Mittal P;Clavaud C;Dhakan DB;Hegde P;Veeranagaiah MM;Saha S;Souverain L;Roy N;Breton L;Misra N;Sharma VK
来自不同人群的几项头皮微生物组研究揭示了头皮屑与细菌和真菌生态失调的关系。然而，头皮微生物群在头皮疾病和健康中的功能作用仍然很少探索。在这里，我们研究了头皮微生物组的细菌和真菌多样性，以及它们在140名印度女性健康和头皮屑头皮中的潜在功能作用。痤疮丙酸杆菌和表皮葡萄球菌成为核心细菌物种，前者与健康的头皮有关，后者与头皮屑有关。沿着常见的马拉色菌属（M. restricta和M.在头皮上的头皮屑（例如，球形菌）中，在核心真菌生物群系中观察到头皮屑与尚未表征的马拉色菌属物种的显著高关联。功能分析表明，真菌微生物组富含主要涉及头皮屑头皮中细胞-宿主粘附的途径，而细菌微生物组显示出与氨基酸，生物素和其他B族维生素的合成和代谢相关的途径的明显富集，这些维生素被报道为头发生长的必需营养素。还对头皮临床和生理参数进行了系统测量，结果显示与微生物组及其相关功能途径具有显著相关性。这些结果指出了细菌微生物群在维持头皮营养稳态方面的新的潜在作用，并强调了头皮微生物组的重要但未知的作用，类似于肠道微生物组。因此，这项研究为更好地理解头皮屑的病理生理学提供了新的视角。
Several scalp microbiome studies from different populations have revealed the association of dandruff with bacterial and fungal dysbiosis. However, the functional role of scalp microbiota in scalp disorders and health remains scarcely explored. Here, we examined the bacterial and fungal diversity of the scalp microbiome and their potential functional role in the healthy and dandruff scalp of 140 Indian women. Propionibacterium acnes and Staphylococcus epidermidis emerged as the core bacterial species, where the former was associated with a healthy scalp and the latter with dandruff scalp. Along with the commonly occurring Malassezia species (M. restricta and M. globosa) on the scalp, a strikingly high association of dandruff with yet uncharacterized Malassezia species was observed in the core mycobiome. Functional analysis showed that the fungal microbiome was enriched in pathways majorly implicated in cell-host adhesion in the dandruff scalp, while the bacterial microbiome showed a conspicuous enrichment of pathways related to the synthesis and metabolism of amino acids, biotin, and other B-vitamins, which are reported as essential nutrients for hair growth. A systematic measurement of scalp clinical and physiological parameters was also carried out, which showed significant correlations with the microbiome and their associated functional pathways. The results point toward a new potential role of bacterial commensals in maintaining the scalp nutrient homoeostasis and highlights an important and yet unknown role of the scalp microbiome, similar to the gut microbiome. This study, therefore, provides new perspectives on the better understanding of the pathophysiology of dandruff.