The Embryonic Mouse Hindbrain and Postnatal Retina as In Vivo Models to Study Angiogenesis.
The Embryonic Mouse Hindbrain and Postnatal Retina as In Vivo Models to Study Angiogenesis.
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胚胎小鼠后脑和产后视网膜作为研究血管生成的体内模型。
DOI：
10.1007/978-1-0716-2217-9_20
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Fantin A
中科院分区：
文献类型：
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作者：
Fantin A
血管生成，即从原有血管中生成新血管，是器官发育、运动诱导的肌肉生长和伤口愈合的基本过程，但也与癌症和新生血管性眼病等不同疾病有关。因此，阐明血管生成的分子和细胞机制有可能确定新的治疗靶点，以刺激缺血组织中的新血管形成或抑制疾病中的病理性血管生长。本章描述了小鼠胚胎后脑和出生后视网膜作为研究生理性血管生成的模型，并提供了详细的组织解剖、样品染色和分析方案。
Angiogenesis, the growth of new blood vessels from pre-existing ones, is a fundamental process for organ development, exercise-induced muscle growth, and wound healing, but is also associated with different diseases such as cancer and neovascular eye disease. Accordingly, elucidating the molecular and cellular mechanisms of angiogenesis has the potential to identify new therapeutic targets to stimulate new vessel formation in ischemic tissues or inhibit pathological vessel growth in disease. This chapter describes the mouse embryo hindbrain and postnatal retina as models to study physiological angiogenesis and provides detailed protocols for tissue dissection, sample staining and analysis.