Failed Recovery of Glycemic Control and Myofibrillar Protein Synthesis With 2 wk of Physical Inactivity in Overweight, Prediabetic Older Adults
Failed Recovery of Glycemic Control and Myofibrillar Protein Synthesis With 2 wk of Physical Inactivity in Overweight, Prediabetic Older Adults
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DOI：
10.1093/gerona/glx203
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发表时间：
2018-08-01
影响因子：
5.1
通讯作者：
Phillips, Stuart M.
中科院分区：
文献类型：
--
作者：
McGlory, Chris;von Allmen, Mark T.;Phillips, Stuart M.
背景：缺乏体力活动会损害胰岛素敏感性，并随着年龄的增长而加剧。我们研究了2周的急性不活动和恢复对血糖控制的影响，以及老年男性和女性肌肉蛋白合成的综合速率。方法：22名超重、糖尿病前期老年人（12名男性，10名女性，69 +/- 4岁）进行了7天的习惯性活动（基线; BL），减少步数（SR;
Background: Physical inactivity impairs insulin sensitivity, which is exacerbated with aging. We examined the impact of 2 wk of acute inactivity and recovery on glycemic control, and integrated rates of muscle protein synthesis in older men and women.Methods: Twenty-two overweight, prediabetic older adults (12 men, 10 women, 69 +/- 4 y) undertook 7 d of habitual activity (baseline; BL), step reduction (SR;