Short-term and long-term cellular and molecular events following UV irradiation of skin: implications for molecular medicine.
Short-term and long-term cellular and molecular events following UV irradiation of skin: implications for molecular medicine.
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DOI：
10.1017/s146239940200532x
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发表时间：
2002-12-02
影响因子：
6.2
通讯作者：
Ananthaswamy, Honnavara N
中科院分区：
文献类型：
--
作者：
Matsumura, Yasuhiro;Ananthaswamy, Honnavara N
正常人体皮肤的急性紫外线（UV）照射会导致几种临床效应，包括晒伤炎症（红斑）和晒黑，组织学变化，如表皮增厚，以及局部或全身免疫抑制。慢性紫外线照射导致光老化、持续免疫抑制和光致癌作用。光致癌作用涉及遗传变化的积累以及免疫系统调节，并最终导致皮肤癌的发展。分子和细胞生物学的最新进展阐明了光致癌的机制，包括DNA光产物的形成、DNA修复、原癌基因和肿瘤抑制基因的突变以及UV诱导的免疫抑制。进一步研究和更好地了解光致癌作用对人类皮肤癌的有效预防和干预策略的发展至关重要。
Acute ultraviolet (UV) irradiation of normal human skin results in several clinical effects, including sunburn inflammation (erythema) and tanning, histological changes such as thickening of the epidermis, and local or systemic immunosuppression. Chronic UV irradiation leads to photoaging, sustained immunosuppression and photocarcinogenesis. Photocarcinogenesis involves the accumulation of genetic changes, as well as immune system modulation, and ultimately leads to the development of skin cancers. Recent advances in molecular and cellular biology have clarified the mechanisms of photocarcinogenesis, including the formation of DNA photoproducts, DNA repair, the mutation of proto-oncogenes and tumour suppressor genes, and UV-induced immunosuppression. Further investigation and a better understanding of photocarcinogenesis are critical to the development of effective prevention and intervention strategies for human skin cancer.