Cortical Microinfarcts Detected In Vivo on 3 Tesla MRI Clinical and Radiological Correlates
Cortical Microinfarcts Detected In Vivo on 3 Tesla MRI Clinical and Radiological Correlates
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DOI：
10.1161/strokeaha.114.007568
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发表时间：
2015-01-01
期刊：
影响因子：
8.3
通讯作者：
Richard, Edo
中科院分区：
文献类型：
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作者：
van Dalen, Jan Willem;Scuric, Eva E. M.;Richard, Edo
背景和目的：皮层微梗死（CMIs）是一种常见的死后发现，与血管危险因素、认知能力下降和痴呆有关。最近，在7特斯拉MRI上发现的CMIs在3特斯拉MRI上也被证明是可追溯的。方法：我们对194名患有收缩期高血压的非痴呆老年人（72-80岁）进行了3次特斯拉MRI评估。采用病例对照设计，比较有和没有CMIs的参与者的年龄、性别、心血管危险因素和白质高强度体积。结果：我们在12名参与者（6%）中确定了23例cmi。CMIs与年龄较大、舒张压较高和近期卒中史有关。cmi患者有较高白质高强度体积的趋势。结论：我们发现CMIs与临床参数相关，包括年龄和心血管危险因素。虽然CMIs的患病率相对较低，但我们的研究结果表明，使用3特斯拉MRI在更大规模的临床研究中研究CMIs是可能的。这开启了对老年CMIs临床相关性进行大规模前瞻性研究的可能性。
Background and Purpose-Cortical microinfarcts (CMIs) are a common postmortem finding associated with vascular risk factors, cognitive decline, and dementia. Recently, CMIs identified in vivo on 7 Tesla MRI also proved retraceable on 3 Tesla MRI.Methods-We evaluated CMIs on 3 Tesla MRI in a population-based cohort of 194 nondemented older people (72-80 years) with systolic hypertension. Using a case-control design, participants with and without CMIs were compared on age, sex, cardiovascular risk factors, and white matter hyperintensity volume.Results-We identified 23 CMIs in 12 participants (6%). CMIs were associated with older age, higher diastolic blood pressure, and a history of recent stroke. There was a trend for a higher white matter hyperintensity volume in participants with CMIs.Conclusions-We found an association of CMIs with clinical parameters, including age and cardiovascular risk factors. Although the prevalence of CMIs is relatively low, our results suggest that the study of CMIs in larger clinical studies is possible using 3 Tesla MRI. This opens the possibility of large-scale prospective investigation of the clinical relevance of CMIs in older people.