Attenuation of chronic hypoxic pulmonary hypertension by simvastatin
Attenuation of chronic hypoxic pulmonary hypertension by simvastatin
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DOI：
10.1152/ajpheart.01097.2002
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发表时间：
2003-09-01
影响因子：
4.8
通讯作者：
Johns, RA
中科院分区：
文献类型：
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作者：
Girgis, RE;Li, DC;Johns, RA
3-羟基-3-甲基戊二酰辅酶A还原酶抑制剂（他汀类药物）已被证明可改善多种正常内皮细胞功能并抑制血管壁细胞增殖。我们假设辛伐他汀可以减轻慢性低氧性肺动脉高压。将雄性成年Sprague-Dawley大鼠暴露于常氧（N）、常氧加每日一次辛伐他汀（20 mg/kg ip）（NS）、缺氧（10%吸入O-2分数）（H）或缺氧加辛伐他汀（HS）（14天）。用开胸法测量麻醉、通气大鼠的平均肺动脉压，从H组的25 ± 2 mmHg降至HS组的18 ± 1 mmHg（P
The 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) have been shown to improve multiple normal endothelial cell functions and inhibit vascular wall cell proliferation. We hypothesized that one such agent, simvastatin, would attenuate chronic hypoxic pulmonary hypertension. Male adult Sprague-Dawley rats were exposed (14 days) to normoxia (N), normoxia plus once-a-day administered simvastatin (20 mg/kg ip) (NS), hypoxia (10% inspired O-2 fraction) (H), or hypoxia plus simvastatin (HS). Mean pulmonary artery pressure, measured in anesthetized, ventilated rats with an open-chest method, was reduced from 25+/-2 mmHg in H to 18+/-1 in HS (P