Endothelial expression of the Notch ligand Jagged1 is required for vascular smooth muscle development
Endothelial expression of the Notch ligand Jagged1 is required for vascular smooth muscle development
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DOI：
10.1073/pnas.0709663105
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发表时间：
2008-02-12
影响因子：
11.1
通讯作者：
Epstein, Jonathan A.
中科院分区：
文献类型：
--
作者：
High, Frances A.;Lu, Min Min;Epstein, Jonathan A.
Notch配体Jagged1（Jag1）对血管重塑至关重要，并与人类先天性心脏病有关，但其在心血管系统各种细胞类型中的确切作用尚未得到广泛研究。我们发现，内皮特异性缺失的Jag1的胚胎致死性和心血管缺陷的结果，重演的Jag1空表型。这些胚胎在血管平滑肌中表现出明显的缺陷，而内皮Notch激活和动静脉分化似乎正常。内皮Jag1突变胚胎与内皮Notch信号被抑制的胚胎在表型上不同。总之，这些结果意味着内皮Jag1的主要作用是增强邻近血管平滑肌的发育。
The Notch ligand Jagged1 (Jag1) is essential for vascular remodeling and has been linked to congenital heart disease in humans, but its precise role in various cell types of the cardiovascular system has not been extensively investigated. We show that endothelial-specific deletion of Jag1 results in embryonic lethality and cardiovascular defects, recapitulating the Jag1 null phenotype. These embryos show striking deficits in vascular smooth muscle, whereas endothelial Notch activation and arterial-venous differentiation appear normal. Endothelial Jag1 mutant embryos are phenotypically distinct from embryos in which Notch signaling is inhibited in endothelium. Together, these results imply that the primary role of endothelial Jag1 is to potentiate the development of neighboring vascular smooth muscle.