Adjuvant transcatheter arterial chemoembolization improves efficacy of hepatectomy for patients with hepatocellular carcinoma and portal vein tumor thrombus
Adjuvant transcatheter arterial chemoembolization improves efficacy of hepatectomy for patients with hepatocellular carcinoma and portal vein tumor thrombus
复制标题
辅助经导管动脉化疗栓塞术提高肝细胞癌合并门静脉癌栓患者肝切除术的疗效
DOI：
10.1016/j.amjsurg.2008.09.026
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发表时间：
2009-09-01
影响因子：
3
通讯作者：
Zhou, Fan
中科院分区：
文献类型：
--
作者：
Peng, Bao-Gang;He, Qiang;Zhou, Fan
目的：探讨术后经导管动脉化疗栓塞（TACE）对提高肝细胞癌（HCC）和门静脉癌栓（PVTT）患者肝切除和肿瘤、血栓清除效果的价值。 实验设计：1996年1月至2004年12月，126例HCC和PVTT患者被随机分为2组：对照组和对照组。泰塞组。对照组行肝切除联合PVTT切除,TACE组行肝切除联合术后辅助TACE。研究了两组的生存时间。结果：两组的所有临床病理数据具有可比性。 TACE 组的中位生存时间为 13 个月（95% 置信区间 [CI] 6.25 至 19.75 个月），对照组为 9 个月（95% CI 6.90 至 11.10 个月）。 TACE 组的 1 年、3 年和 5 年估计生存率（分别为 50.9%、33.8%、21.5%）优于对照组（分别为 33.3%、17.0%、8.5%；对数秩 P = 0.0094）。结论：对于患有 PVTT 的 HCC 患者，术后 TACE 增强了肝切除联合 PVTT 切除的效果。 (C) 2009 Elsevier Inc. 保留所有权利。
PURPOSE: To study the value of postoperative transcatheter arterial chemoembolization (TACE) to improve the efficacy of hepatectomy and tumor, thrombus removal for patients with hepatocellular carcinoma (HCC) and portal vein tumor thrombus (PVTT).EXPERIMENTAL DESIGN: From January 1996 to December 2004, 126 patients with HCC and PVTT were randomly assigned into 2 groups: a control group and a TACE group. The control group underwent liver resection combined with PVTT removal, and the TACE group underwent liver resection combined with adjuvant TACE after surgery. Survival time in the 2 groups was studied.RESULTS: The 2 groups were comparable with regard to all clinicopathologic data. The median survival time was 13 months (95% confidence interval [CI] 6.25 to 19.75 months) for the TACE group and 9 months (95% CI 6.90 to 11.10 months) for the control group. Estimated Survival rates for 1, 3 and 5 years were better in the TACE group (50.9%, 33.8%, 21.5%; respectively) than the control group (33.3%, 17.0%, 8.5%, respectively; log rank P = .0094).CONCLUSIONS: Postoperative TACE enhances the effect of liver resection combined with PVTT removal for HCC patients with PVTT. (C) 2009 Elsevier Inc. All rights reserved.