Neuroendocrine and behavioral response to social confrontation: residents versus intruders, active versus passive coping styles
Neuroendocrine and behavioral response to social confrontation: residents versus intruders, active versus passive coping styles
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DOI：
10.1016/j.yhbeh.2004.08.002
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发表时间：
2005-01-01
影响因子：
3.5
通讯作者：
Engelmann, M
中科院分区：
文献类型：
--
作者：
Ebner, K;Wotjak, CT;Engelmann, M
在目前的研究中，我们调查了社会对抗的入侵者和常驻大鼠的神经内分泌相关性。成年雄性Wistar大鼠(入侵者)被引入一位训练有素的居民的家庭笼子中，以在用铁丝网分开之前诱导包括物理攻击在内的特征激励性相互作用。通过长期置入颈静脉导管和针对下丘脑室旁核(PVN)的微透析探头分别监测下丘脑-垂体-肾上腺(HPA)轴的活动和下丘脑内精氨酸加压素(AVP)的释放。根据在30分钟的对峙中收集的行为数据，入侵者和居民被进一步分为两个不同的亚组：几乎没有冰冻行为的入侵者(主动守卫)和表现出明显冰冻行为的入侵者(被动守卫)和以攻击性或非攻击性为主的居民。神经内分泌数据显示，在两个入侵者亚组中，社会对抗导致血浆促肾上腺皮质激素(ACTH)分泌显著增加，与他们的应对策略无关。相反，只有在非攻击性动物的社会对抗中，居民的血浆ACTH才会增加，而攻击性的居民则没有引起ACTH的反应。有趣的是，在积极的入侵者中，血浆AVP随着社会对抗的反应而降低。在微透析液中，两组居民和被动入侵者的PVN内AVP释放没有明显变化。相反，这种神经肽在PVN内的释放增加可以被监测到是否有活跃的入侵者。本研究的数据表明，对厌恶遭遇的不同解释导致入侵者和居住者的神经内分泌反应和下丘脑内加压素能信号的不同。(C)2004 Elsevier Inc.保留所有权利。
We investigated in the present study the neuroendocrine correlates in intruder and resident rats of a social confrontation. Adult male Wistar rats (intruders) were introduced into the home cage of a well-trained resident to induce characteristic agonistic interactions including physical attacks prior to separation by a wire mesh. The hypothalamic-pituitary-adrenal (HPA) axis activity and the intrahypothalamic release of arginine vasopressin (AVP) were monitored via chronically implanted jugular venous catheters and microdialysis probes aimed at the hypothalamic paraventricular nucleus (PVN), respectively. Based on the behavioral data collected during the 30-min confrontation, intruders and residents were additionally classified into two different subgroups: intruders which showed almost no freezing behavior (active copers) versus those showing pronounced freezing behavior (passive copers) and residents which were either predominantly aggressive or non-aggressive. The neuroendocrine data show that social confrontation caused a significantly increased secretion of the adrenocorticotropic hormone (ACTH) into plasma in both intruder subgroups, independently of their coping strategy. In contrast, plasma ACTH in residents was increased in response to social confrontation in non-aggressive animals only, whereas aggressive residents failed to mount an ACTH response. Interestingly, plasma AVP decreased in response to social confrontation in active intruders. As measured in microdialysates, the two groups of residents and passive intruders failed to show significant changes of intra-PVN release of AVP. In contrast, an increased release of this neuropeptide within the PVN could be monitored for active intruders. The data of the present study suggest that the different interpretation of an aversive encounter results in differences in the neuroendocrine response and intrahypothalamic vasopressinergic signaling in intruders versus residents. (C) 2004 Elsevier Inc. All rights reserved.