Dorsal-ventral signaling in the Drosophila eye.
Dorsal-ventral signaling in the Drosophila eye.
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DOI：
10.1126/science.281.5385.2031
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发表时间：
1998-09
期刊：
影响因子：
56.9
通讯作者：
V. Papayannopoulos;Andrew Tomlinson;Vladislav M. Panin;C. Rauskolb;Kenneth D. Irvine
中科院分区：
文献类型：
--
作者：
V. Papayannopoulos;Andrew Tomlinson;Vladislav M. Panin;C. Rauskolb;Kenneth D. Irvine
果蝇眼睛的发育已经成为研究组织模式和细胞间通讯的模型系统;然而，早期眼睛的发育还没有得到很好的理解。这里提供的结果表明，通过Notch介导的背侧和腹侧细胞之间的信号传导，特化细胞沿着发育中的眼睛的背腹中线建立，并且中线的Notch激活在促进眼睛原基的生长方面发挥着重要作用。并调节眼睛图案。这些观察结果意味着果蝇翅膀和脊椎动物四肢之间的发育同源性延伸到果蝇的眼睛。
The development of the Drosophila eye has served as a model system for investigations of tissue patterning and cell-cell communication; however, early eye development has not been well understood. The results presented here indicate that specialized cells are established along the dorsal-ventral midline of the developing eye by Notch-mediated signaling between dorsal and ventral cells, and that Notch activation at the midline plays an essential role both in promoting the growth of the eye primordia and in regulating eye patterning. These observations imply that the developmental homology between Drosophila wings and vertebrate limbs extends to Drosophila eyes.