Chronic subclinical inflammation as part of the insulin resistance syndrome -: The Insulin Resistance Atherosclerosis Study (IRAS)
Chronic subclinical inflammation as part of the insulin resistance syndrome -: The Insulin Resistance Atherosclerosis Study (IRAS)
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DOI：
10.1161/01.cir.102.1.42
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发表时间：
2000-07-04
期刊：
影响因子：
37.8
通讯作者：
Haffner, SM
中科院分区：
文献类型：
--
作者：
Festa, A;D'Agostino, R;Haffner, SM
背景：炎症已被认为是动脉粥样硬化发展的一个危险因素。近年来，胰岛素抵抗综合征（IRS）的一些成分与炎症标志物有关。我们假设，直接测量的胰岛素不敏感可能与非糖尿病受试者的炎症有关。方法和结果：我们研究了胰岛素抵抗动脉粥样硬化研究（IRAS）中非糖尿病人群中c反应蛋白（CRP）、纤维蛋白原和白细胞计数与IRS成分的关系（n=1008，年龄40 - 69岁，33%糖耐量受损），这是一项多中心、基于人群的研究。所有受试者均无临床冠状动脉疾病。胰岛素敏感性（S-1）通过频繁采样的静脉葡萄糖耐量试验来测量，CRP通过高灵敏度的竞争性免疫分析法来测量，所有3种炎症标志物都与IRS的几个成分相关。发现CRP与体脂（体重指数、腰围）、S-1、空腹胰岛素和胰岛素原之间存在很强的相关性(所有相关系数>.3，P
Background-Inflammation has been suggested as a risk factor for the development of atherosclerosis. Recently, some components of the insulin resistance syndrome (IRS) have been related to inflammatory markers. We hypothesized that insulin insensitivity, as directly measured, may be associated with inflammation in nondiabetic subjects.Methods and Results-We studied the relation of C-reactive protein (CRP), fibrinogen, and white cell count to components of IRS in the nondiabetic population of the Insulin Resistance Atherosclerosis Study (IRAS) (n=1008; age, 40 to 69 years; 33% with impaired glucose tolerance), a multicenter, population-based study. None of the subjects had clinical coronary artery disease. Insulin sensitivity (S-1) was measured by a frequently sampled intravenous glucose tolerance test, and CRP was measured by a highly sensitive competitive immunoassay, All 3 inflammatory markers were correlated with several components of the IRS. Strong associations were found between CRP and measures of body fat (body mass index, waist circumference), S-1, and fasting insulin and proinsulin (all correlation coefficients >0.3, P