Conditioned stress-induced analgesia in humans
Conditioned stress-induced analgesia in humans
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DOI：
10.1016/s1090-3801(99)90013-7
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发表时间：
1999-01-01
期刊：
影响因子：
--
通讯作者：
Grüsser, SM
中科院分区：
文献类型：
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作者：
Flor, H;Grüsser, SM
本实验的目的是证明人类条件应激诱导的镇痛。在基线日（第1天）之后，两组10名受试者分别暴露于绿色光作为条件刺激（CS）和心算加噪声作为非条件刺激（US）5天（第2-6天），第三组10名受试者仅暴露于US。在实验当天（第7天），测试疼痛阈值和疼痛耐受性，而组1和组3接受经修饰的光CS，组2不接受CS。第一组在测试当天表现出显著更高的痛阈和更高的疼痛耐受性，而两个对照组没有改变疼痛感知。心率数据证实了成功的应激诱导。心率和血压在测试当天没有改变，因此不太可能对调节作用进行心血管介导。条件应激镇痛可能有助于理解慢性疼痛综合征。(C)1999年国际疼痛研究协会欧洲分会联合会。
The purpose of this experiment was the demonstration of conditioned stress-induced analgesia in humans. Following a baseline day (day 1), two groups of 10 subjects were each exposed to green light as the conditioned stimulus (CS) and mental arithmetic plus noise as the unconditioned stimulus (US) for 5 days (days 2-6), a third group of 10 subjects was only exposed to the US. On the test day (day 7), pain threshold and pain tolerance were tested, while groups 1 and 3 received the preen light CS and group 2 received no CS. Group I showed a significantly higher pain threshold and higher pain tolerance on the test day, whereas the two control groups did not have altered pain perception. Heart rate data confirmed successful stress induction. Heart rate and blood pressure were unaltered on the test day, thus making cardiovascular mediation of the conditioning effect unlikely. Conditioned stress analgesia might be useful in the understanding of chronic pain-syndromes. (C) 1999 European Federation of Chapters of the International Association for the Study of Pain.