Gels of Pluronic F127 and nonionic surfactants from rheological characterization to controlled drug permeation
Gels of Pluronic F127 and nonionic surfactants from rheological characterization to controlled drug permeation
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DOI：
10.1016/j.colsurfb.2011.04.033
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发表时间：
2011-10-01
影响因子：
5.8
通讯作者：
Ranieri, Giuseppe Antonio
中科院分区：
文献类型：
--
作者：
Antunes, Filipe E.;Gentile, Luigi;Ranieri, Giuseppe Antonio
非离子囊泡的作用上的流变行为的普朗尼克F127的研究以上的稀释制度和非离子表面活性剂的浊点以下。F127是一种具有溶胶-凝胶转变的共聚物，其热转变归因于从胶束到立方相的相变。预期表面活性剂囊泡的存在增强多种药物的区室化，而与它们对溶剂的亲和力无关。这种包封将适用于药物在不同应用中的控制释放。我们在这里讨论了Pluronic-非离子表面活性剂混合体系，特别强调了表面活性剂对Pluronic流变学性质的影响，结果表明，共混体系的流变学性质主要由聚合物本身的行为决定，该混合系统可用于控制小分子药物如双氯芬酸钠盐的经皮渗透。(C)2011爱思唯尔有限公司版权所有。
The role of nonionic vesicles on the theological behavior of Pluronic F127 is investigated above the dilute regime and below the cloud point of the nonionic surfactant. F127 is a copolymer possessing sol-gel transition by heating attributed to a phase transition from micellar to cubic. The presence of surfactant vesicles is expected to enhance the compartmentalization of a variety of drugs, independently of their affinity to the solvent. Such entrapment would be suitable for controlled release of the drugs in different applications.We address here a mixed Pluronic-nonionic surfactant system with particular emphasis to the effects of the surfactant on the rheological properties of the Pluronics, and the correlation between these properties and drug release control.The results show that the theological properties of the mixed system are mainly governed by the behavior of the polymer alone and that the mixed system can be useful to control the percutaneous permeation of a small drug, such as Diclofenac Sodium salt. (C) 2011 Elsevier B.V. All rights reserved.