TICK-BORNE TULAREMIA - AN OUTBREAK OF LYMPHADENOPATHY IN CHILDREN
TICK-BORNE TULAREMIA - AN OUTBREAK OF LYMPHADENOPATHY IN CHILDREN
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DOI：
10.1001/jama.254.20.2922
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发表时间：
1985-01-01
影响因子：
120.7
通讯作者：
KAUFMANN, AF
中科院分区：
文献类型：
--
作者：
MARKOWITZ, LE;HYNES, NA;KAUFMANN, AF
1984 年 6 月 1 日至 7 月 15 日期间，南达科他州 Lower Brule 和 Crow Creek 印第安保留地发现了 20 名腺兔热病患者。患者的中位年龄为 6 岁（范围为 2 至 20 岁）。临床症状轻微，包括发烧、头痛和淋巴结肿大。所有淋巴结肿大均位于头部和颈部区域。变异革蜱被鉴定为媒介。尽管轻微的临床症状表明 B 型土拉弗朗西斯菌是病原体，但从该地区的狗身上采集的蜱中分离出了 A 型和 B 型土拉弗朗西斯菌。在北美，兔热病通常被认为是一种严重的全身性疾病。这次爆发表明它可能是一种轻微的疾病，A 型和 B 型毒株都可以通过蜱传播并在同一生态系统中共存。
Between June 1 and July 15, 1984, twenty persons with glandular tularemia were identified on the Lower Brule and Crow Creek Indian reservations in South Dakota. The median age of the patients was 6 years (range, 2 to 20 years). The clinical illness was mild, consisting of fever, headache, and lymphadenopathy. All lymphadenopathy was in the head and neck area. Dermacentor variabilis ticks were identified as the vector. Although the mild clinical illness suggested Francisella tularensis, type B, was the agent, both type A and type B strains of F. tularensis were isolated from ticks collected from dogs in the area. Tularemia is generally thought to be a severe systemic illness in North America. This outbreak illustrates that it can be a mild disease and that both A and type B strains can be tick-borne and coexist in the same ecosystem.