MRI-guided thermal therapy of transplanted tumors in the canine prostate using a directional transurethral ultrasound applicator
MRI-guided thermal therapy of transplanted tumors in the canine prostate using a directional transurethral ultrasound applicator
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DOI：
10.1002/jmri.10076
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发表时间：
2002-04-01
影响因子：
4.4
通讯作者：
Stafford, RJ
中科院分区：
文献类型：
--
作者：
Hazle, JD;Diederich, CJ;Stafford, RJ
目的：为了评估MRI为基础的技术，在体内犬前列腺model.Materials和方法植入肿瘤经尿道超声热疗法的视觉引导，热监测和评估：传染性性病肿瘤（TVT）生长在右叶的前列腺在四只狗。采用经尿道180度定向加热超声刀对肿瘤进行选择性高温热疗。使用快速交错梯度回波回波平面（iGE-EPI）成像序列的温度敏感MRI（MRTI）用于治疗期间多个图像平面中的累积热剂量计算。从MRTI为基础的剂量地图和治疗后MRI的结果进行了比较，从组织学analysis.Results：MRTI监测在多个平面的前列腺指导使用和控制的一个定向超声探头的选择性消融的部分，包含植入肿瘤的前列腺。热疗后立即获得的钆增强MRI的发现稍微低估了治疗后组织坏死的大小，证实了组织病理学analysis.Conclusion：使用多平面磁共振成像与经尿道超声喷头显示出显着的潜力，选择性热消融的前列腺肿瘤和组织。
Purpose: To evaluate MRI-based techniques for visual guidance, thermal monitoring, and assessment during transurethral ultrasound thermal therapy of implanted tumors in an in vivo canine prostate model.Materials and Methods: Transmissible venereal tumors (TVT) were grown in the right lobe of the prostate in four dogs. High-temperature thermal therapy was selectively applied to the tumor-bearing lobe using a transurethral ultrasound applicator with a 180degrees directional heating pattern. Temperature-sensitive MRI (MRTI) using a fast interleaved gradient-echo echo-planar (iGE-EPI) imaging sequence was used for cumulative thermal dose calculations in multiple image planes during the treatment. The results from MRTI-based dose maps and post-treatment MRI were compared to those from histologic analysis.Results: MRTI monitoring in multiple planes across the prostate guided the use and control of a directive ultrasound applicator for the selective ablation of the sections of the prostate that contained implanted tumors. Findings in gadolinium enhanced MRI obtained immediately after thermal therapy slightly underestimated the size of tissue necrosis after treatment, as verified by histopathologic analysis.Conclusion: The use of multiplanar MRTI with a transurethral ultrasound applicator shows significant potential for selective thermal ablation of prostate tumor and tissue.