Dietary fiber, glycemic index, glycemic load and renal cell carcinoma risk
Dietary fiber, glycemic index, glycemic load and renal cell carcinoma risk
复制标题
膳食纤维、血糖指数、血糖负荷和肾细胞癌风险
DOI：
10.1093/carcin/bgz049
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发表时间：
2019
期刊：
影响因子：
4.7
通讯作者：
Wang Song
中科院分区：
文献类型：
--
作者：
Xu Xin;Zhu Yi;Li Jiangfeng;Wang Song
多项流行病学研究调查了膳食纤维、血糖指数 (GI) 或血糖负荷 (GL) 与肾细胞癌 (RCC) 风险之间的潜在关联，但结果不一致。本研究的目的是通过荟萃分析方法系统地评估这个问题。在 PubMed 和 Web of Science 数据库中进行了截至 2018 年 3 月的全面文献检索。摘要相对风险 (RR) 和 95% 置信区间 (CI) 通过随机效应模型进行估计。本研究最终纳入了 12 项研究（8 项针对纤维分析，5 项针对 GI，5 项针对 GL）。 GI 与 RCC 风险之间存在显着正相关（总体 RR 1.16，95% CI 1.02–1.32），并且研究之间未检测到显着异质性（I2= 22.8%，P= 0.262）。纤维摄入量与肾细胞癌风险之间存在显着的负相关关系（总体 RR 0.82，95% CI 0.72–0.92），并且各项研究中未观察到显着的异质性（I2= 27.6%，P= 0.218）。 GL 与 RCC 风险不显着相关（总体 RR 1.14，95% CI 0.81–1.60），并且各研究之间发现显着异质性（I2= 78.6%，P< 0.001）。总之，这项系统回顾和荟萃分析表明膳食GI和纤维可能与肾细胞癌风险相关。仍需要进一步的大型前瞻性队列研究来证实我们的初步发现。
Several epidemiological studies have investigated the potential association between dietary fiber, glycemic index (GI) or glycemic load (GL), and renal cell carcinoma (RCC) risk with inconsistent results. The aim of this study was to systematically evaluate this issue with a meta-analysis approach. A comprehensive literature search up to March 2018 was performed in PubMed and Web of Science databases. Summary relative risks (RRs) and 95% confidence intervals (CIs) were estimated with a random-effects model. Twelve studies were finally included in this study (eight for fiber analysis, five for GI and five for GL). A significant positive association was observed between GI and the risk of RCC (summary RR 1.16, 95% CI 1.02–1.32), and no significant heterogeneity was detected among studies (I2= 22.8%,P= 0.262). A significant inverse association was found between fiber intake and the risk of RCC (summary RR 0.82, 95% CI 0.72–0.92), and no significant heterogeneity was observed across studies (I2= 27.6%,P= 0.218). GL was not significantly associated with RCC risk (summary RR 1.14, 95% CI 0.81–1.60), and significant heterogeneity was found across studies (I2= 78.6%,P< 0.001). In conclusion, this systematic review and meta-analysis suggests that dietary GI and fiber may be associated with the risk of RCC. Further large prospective cohort studies are still warranted to confirm our preliminary findings.