RECENT RESULTS OF ORAL-CANCER RESEARCH IN KERALA, INDIA
RECENT RESULTS OF ORAL-CANCER RESEARCH IN KERALA, INDIA
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DOI：
10.1002/hed.2880140206
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发表时间：
1992-03-01
影响因子：
2.9
通讯作者：
DUTT, SC
中科院分区：
文献类型：
--
作者：
SANKARANARAYANAN, R;NAIR, MK;DUTT, SC
本文回顾了印度喀拉拉邦特里凡得琅地区癌症中心口腔癌研究项目的结果。 有证据表明口腔癌患者的免疫功能受损。 植物凝集素在各种口腔癌前病变和不同组织学亚型的口腔癌中的特异性结合特性正在研究中。 烟草和酒精已被确定为口腔癌的主要危险因素。 类胡萝卜素和类维生素A的化学预防潜力已被评估在口腔白斑。 大剂量的β-胡萝卜素和维生素A在25%-50%的试验参与者中诱导了口腔白斑的缓解，这些参与者在试验期间继续吸烟和饮酒。 较低剂量可维持缓解。 不到20%的口腔癌患者最初出现在局部阶段。 正在评估各种以社区为导向的预防原发性和继发性口腔癌的方案。 这些措施包括反烟草健康教育、口腔自我检查和由经过培训的志愿者进行口腔检查。 并讨论了放射治疗失败后的根治性放疗和手术挽救的结果。 34%的5年无病生存率反映了最初发现时疾病的晚期阶段。 放射治疗失败的手术挽救率令人鼓舞。
Findings from a research program in oral cancer at Regional Cancer Center, Trivandrum, Kerala, India are reviewed. There is evidence of immune impairment in oral cancer patients. Plant lectins are being investigated for specific binding characteristics in various oral precancers and different histological subtypes of oral cancer. Tobacco and alcohol have been identified as the major risk factors for oral cancer. The chemopreventive potential of carotenoids and retinoids have been evaluated in oral leucoplakias. Beta-carotene and vitamin A in heavier doses induced remission of oral leukoplakias in 25%-50% of trial participants who continued with their tobacco and alcohol habits during the trial. The remission could be maintained with lower doses. Less than 20% of our patients with oral cancer were initially seen in localized stages. Various community-oriented programs for prevention of primary and secondary oral cancers are being evaluated. These include antitobacco health education, oral self-examination, and oral examination by trained volunteers. The results of radical radiotherapy and surgical salvage of radiation failure are also discussed. The 5-year disease-free survival rate of 34% is a reflection of the advanced stages of the disease when initially seen. Salvage rates with surgery for radiation failures were encouraging.