Variable Cyanobacterial Toxin and Metabolite Profiles across Six Eutrophic Lakes of Differing Physiochemical Characteristics.
Variable Cyanobacterial Toxin and Metabolite Profiles across Six Eutrophic Lakes of Differing Physiochemical Characteristics.
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DOI：
10.3390/toxins9020062
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发表时间：
2017-02-10
期刊：
影响因子：
4.2
通讯作者：
Miller TR
中科院分区：
文献类型：
--
作者：
Beversdorf LJ;Weirich CA;Bartlett SL;Miller TR
由于有害蓝藻水华的存在，淡水资源的未来可持续性受到严重威胁，然而，大多数蓝藻毒素的数量，范围和分布-包括“新兴”毒素和其他生物活性化合物-知之甚少。我们测量了15个蓝藻化合物，包括四个微囊藻毒素（MC），石房蛤毒素（SXT），圆柱精子蛋白（CYL），类毒素-A（ATX）和同型类毒素-A（hATX），两个鱼腥藻毒素（Apt），三个蓝藻毒素（Cpt），微藻毒素（Mgn），和节球藻毒素（NOD）-在六个淡水湖，经常遇到有毒的cHAB。MC，一种人类肝脏毒素，存在于所有六湖，并在80%的所有样本中检测到。同样，在所有湖泊中检测到Apt，Cpt和Mgn，分别约占所有样品的86%，50%和35%。尽管是一个显着的咸水毒素，NOD检测在两个最浅的湖泊Wingra（4.3米）和Koshkonong（2.1米）。所有的化合物都是高度可变的时间和空间。代谢产物的配置文件之间的湖泊有显着差异，表明湖泊的特点影响蓝藻群落和/或代谢产物的生产。了解蓝藻毒素如何分布在富营养化湖泊可能揭示这些代谢产物的生态功能，提供有价值的信息，为他们的补救和清除，并在保护公众健康的援助。
Future sustainability of freshwater resources is seriously threatened due to the presence of harmful cyanobacterial blooms, and yet, the number, extent, and distribution of most cyanobacterial toxins—including “emerging” toxins and other bioactive compounds—are poorly understood. We measured 15 cyanobacterial compounds—including four microcystins (MC), saxitoxin (SXT), cylindrospermopsin (CYL), anatoxin-a (ATX) and homo-anatoxin-a (hATX), two anabaenopeptins (Apt), three cyanopeptolins (Cpt), microginin (Mgn), and nodularin (NOD)—in six freshwater lakes that regularly experience noxious cHABs. MC, a human liver toxin, was present in all six lakes and was detected in 80% of all samples. Similarly, Apt, Cpt, and Mgn were detected in all lakes in roughly 86%, 50%, and 35% of all samples, respectively. Despite being a notable brackish water toxin, NOD was detected in the two shallowest lakes—Wingra (4.3 m) and Koshkonong (2.1 m). All compounds were highly variable temporally, and spatially. Metabolite profiles were significantly different between lakes suggesting lake characteristics influenced the cyanobacterial community and/or metabolite production. Understanding how cyanobacterial toxins are distributed across eutrophic lakes may shed light onto the ecological function of these metabolites, provide valuable information for their remediation and removal, and aid in the protection of public health.