Enamel Lesion Parameter Correlations between Polychromatic Micro-CT and TMR
Enamel Lesion Parameter Correlations between Polychromatic Micro-CT and TMR
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DOI：
10.1177/0022034512444127
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发表时间：
2012-06-01
影响因子：
7.6
通讯作者：
Tagami, J.
中科院分区：
文献类型：
--
作者：
Hamba, H.;Nikaido, T.;Tagami, J.
横向显微放射照相术（TMR）被认为是评价釉质病变的金标准技术。微计算机断层扫描（μ CT）具有非破坏性测量的优点，但多色X射线的射束硬化效应是一个主要缺点。到目前为止，没有研究验证mu CT对TMR的作用。本研究的目的是验证各种X射线条件下釉质病变的mu CT测量值和针对TMR的软件射束硬化校正（BHC）。在不同条件下，用mu CT在100 kV下扫描具有自然白斑病变的人磨牙5 min：50 mu A（0.5 mm Al过滤器），165 mu A（0.5 mm Al/0.3 mm Cu）和200 mu A（0.5 mm Al/0.4 mm Cu），有或没有BHC。灰度值转换成矿物密度值使用phantomy。然后在相同位置制备薄切片用于TMR。损伤深度（LD; μ m）和矿物质损失（Δ Z; vol% μ m）之间进行了比较μ CT和TMR的皮尔逊相关性。在所有条件下，μ CT测量值与TMR相关性良好（LD和Δ Z的p < 0.001，r > 0.86），但不含BHC的0.5 mm Al除外（p > 0.05）。即使没有六六六，组合铝/铜过滤器成功地减少了射束硬化效应。μ CT可用作TMR的非破坏性替代方法，其参数可用于釉质病变的研究。
Transverse microradiography (TMR) is considered as the gold standard technique for the evaluation of enamel lesions. Micro-computed tomography (mu CT) has the advantage of non-destructive measurements, but the beam-hardening effect with polychromatic x-rays is a major drawback. To date, no study has validated mu CT against TMR. The objective of this study was to validate mu CT measurements of enamel lesions under various x-ray conditions and software beam-hardening correction (BHC) against TMR. Human molars with natural white-spot lesions were scanned for 5 min by mu CT at 100 kV in different conditions: 50 mu A (0.5-mm Al filter), 165 mu A (0.5-mm Al/0.3-mm Cu), and 200 mu A (0.5-mm Al/0.4-mm Cu), with or without BHC. Grayscale values were converted into mineral density values using phantoms. Thin sections at the same positions were then prepared for TMR. Lesion depth (LD; mu m) and mineral loss (Delta Z; vol% mu m) were compared between mu CT and TMR by Pearson's correlations. mu CT measurements correlated well with TMR under all conditions (p < 0.001, r > 0.86 for LD and Delta Z), except for 0.5-mm Al without BHC (p > 0.05). Even without BHC, combined Al/Cu filters successfully reduced the beam-hardening effect. mu CT can be used as a non-destructive alternative to TMR with comparable parameters for the study of enamel lesions.