Hypomyopathic Dermatomyositis with Refractory Dermatitis Treated by Low-dose IL-2
Hypomyopathic Dermatomyositis with Refractory Dermatitis Treated by Low-dose IL-2
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DOI：
10.1007/s13555-020-00421-8
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发表时间：
2020-07-09
影响因子：
3.4
通讯作者：
Li, Zhanguo
中科院分区：
文献类型：
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作者：
Miao, Miao;Li, Yuhui;Li, Zhanguo
肌性皮肌炎(DM)表现为与皮肌炎一致的皮肤损害，但临床上没有明显的肌肉无力。皮肤表现通常是难治性的，与伴随的肌肉受累相比，对常规治疗更具抵抗力。我们报告一位61岁的糖尿病肌无力患者，对标准治疗无效，但经小剂量白介素2(IL-2)治疗成功，且无明显副作用。结论：小剂量IL-2是一种安全有效的治疗低肌病DM的方法。
Hypomyopathic dermatomyositis (DM) presents with cutaneous lesions consistent with dermatomyositis but in the absence of clinically appreciable muscle weakness. The cutaneous manifestations are often refractory and more resistant to conventional therapy than concomitant muscle involvement. We present a 61-year-old hypomyopathic patient with DM who failed to respond to standard therapy but was successfully treated by low-dose interleukin-2 (IL-2) with no significant side effects. We conclude that low-dose IL-2 is a safe and effective treatment for hypomyopathic DM.