Effects of postmortem autolysis on the lipids of rat spinal cord.
Effects of postmortem autolysis on the lipids of rat spinal cord.
复制标题
死后自溶对大鼠脊髓脂质的影响。
DOI：
10.1007/bf02892816
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
Horrocks,LA
中科院分区：
文献类型：
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作者：
Torello,LA;Yates,AJ;Horrocks,LA
以死后38°C自溶3min和4h的大鼠脊髓作为全脊髓缺血时脂质变化的模型。脐带孵育3分钟的唯一变化是胆固醇/克鲜重下降了11.7%。孵育4h的脐带显示，每克鲜重的胆固醇下降了11.6%，水分含量增加了5.6%，磷脂酰丝氨酸下降了22%。边际统计学意义的变化包括孵育4h的脐带脂肪磷/克干重增加15%，G4(GM1)1减少15%。因此，自溶过程在全脊髓缺血中的影响很小，现在应该关注外源性致病因素来解释脊髓的这种缺血性变化。我们还报告了在大鼠脊髓中发现的一种碱不稳定的神经节苷脂G1.
The lipid composition of rat spinal cords undergoing postmortem autolysis for 3 min and for 4 h at 38° C was investigated as a model for lipid changes in total spinal cord ischemia. The only change in cords incubated for 3 min was an 11.7% decrease in cholesterol/g fresh weight. The cords incubated for 4 h showed a similar 11.6% decrease in cholesterol/g fresh weight as well as a 5.6% increase in water content and a 22% decrease in phosphatidyl serine. Changes of marginal statistical significance included a 15% increase in lipid phosphorus/g dry wt. and a 15% decrease in G4(GM1)1in the 4 h incubated cords. Therefore, autolytic processes are of little consequence in total spinal cord ischemia and attention should now be focused on exogenous pathogenetic factors to explain such ischemic changes in spinal cord. We also report discovery of an alkali-labile ganglioside, G1ain rat spinal cord.