Threat-induced modulation of hippocampal and striatal memory systems during navigation of a virtual environment
Threat-induced modulation of hippocampal and striatal memory systems during navigation of a virtual environment
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DOI：
10.1016/j.nlm.2020.107160
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发表时间：
2020-02-01
影响因子：
2.7
通讯作者：
Dunsmoor, Joseph E.
中科院分区：
文献类型：
--
作者：
Goodman, Jarid;McClay, Mason;Dunsmoor, Joseph E.
大脑由多个记忆系统组成，它们调节不同类型的导航。海马体对编码和检索异心空间认知地图很重要，而背纹状体介导基于刺激-反应（S-R）关联的程序记忆。这些记忆系统受到情绪唤起的影响是不同的。特别是，啮齿动物的研究表明，压力通常会损害海马体的空间记忆，而它会保留或有时增强纹状体的S-R记忆。情绪唤醒对这些独立的导航记忆系统的影响在人类受试者中得到的关注较少。在实验1中，被试完成了一个依赖海马的空间版本的八臂放射状迷宫，该迷宫需要非中心空间记忆来成功地通过环境。在实验2中，参与者完成了背侧纹状体S-R版本的迷宫，其中不存在非中心空间线索，需要使用S-R导航。在记忆提取过程中，预期焦虑通过手腕受到不愉快电击的威胁来调节。结果表明，在海马体空间任务中，电击威胁与更多的错误和增加非空间导航策略的使用有关，但不影响纹状体S-R任务中的记忆表现。研究结果表明，关于预期焦虑对记忆系统的影响的分离，对理解恐惧和焦虑如何促进人类精神病理学中与记忆相关的症状具有重要意义。
The brain is composed of multiple memory systems that mediate distinct types of navigation. The hippocampus is important for encoding and retrieving allocentric spatial cognitive maps, while the dorsal striatum mediates procedural memories based on stimulus-response (S-R) associations. These memory systems are differentially affected by emotional arousal. In particular, rodent studies show that stress typically impairs hippocampal spatial memory while it spares or sometimes enhances striatal S-R memory. The influence of emotional arousal on these separate navigational memory systems has received less attention in human subjects. We investigated the effect of dynamic changes in anticipatory anxiety on hippocampal spatial and dorsal striatal S-R memory systems while participants attempted to solve a virtual eight-arm radial maze, In Experiment 1, participants completed a hippocampus-dependent spatial version of the eight-arm radial maze that required allocentric spatial memory to successfully navigate the environment. In Experiment 2, participants completed a dorsal striatal S-R version of the maze where no allocentric spatial cues were present, requiring the use of S-R navigation. Anticipatory anxiety was modulated via threat of receiving an unpleasant electrical shock to the wrist during memory retrieval. Results showed that threat of shock was associated with more errors and increased use of non-spatial navigational strategies in the hippocampal spatial task, but did not influence memory performance in the striatal S-R task. Findings indicate a dissociation regarding the influence of anticipatory anxiety on memory systems that has implications for understanding how fear and anxiety contribute to memory-related symptoms in human psychopathologies.