Oxygen consumption of keloids and hypertrophic scars
Oxygen consumption of keloids and hypertrophic scars
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DOI：
10.1097/sap.0b013e318053ec1d
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发表时间：
2008-02-01
影响因子：
1.5
通讯作者：
Nakatsuka, Takashi
中科院分区：
文献类型：
--
作者：
Khioka, Shigeru;Ando, Taichi;Nakatsuka, Takashi
疤痕疙瘩和肥厚性疤痕的耗氧量从未被定量地呈现，尽管异常的代谢状况必须与其病理生理学相关。我们发明了一种配备克拉克氧电极的原始测量系统，用于离体样品。对小鼠伤口愈合模型的测量表明，未成熟的修复组织比成熟组织消耗更多的氧气。这一发现符合当前的想法，并支持了我们测量系统的有效性。对新鲜人体样本的分析清楚地表明，疤痕增生性疤痕的耗氧率较高，而成熟疤痕的耗氧率相对较低。高耗氧潜力以及氧扩散不足可能导致疤痕疙瘩和肥厚性疤痕的病理生理学。
The oxygen consumption of keloids and hypertrophic scars has never been quantitatively presented, although abnormal metabolic conditions must be associated with their pathophysiology. We invented an original measurement system equipped with a Clark oxygen electrode for ex vivo samples. The measurement of a mouse wound-healing model revealed immature repairing tissues consumed more oxygen than mature tissues. This finding is in accord with the current thinking and supported the validity of our measurement system. The analysis of fresh human samples clearly demonstrated the high oxygen consumption rate of keloid hypertrophic scars and the comparatively low consumption of mature scars. A high oxygen consuming potential, as well as insufficient oxygen diffusion, may possibly contribute to the pathophysiology of keloids and hypertrophic scars.