Going mad with Smads
Going mad with Smads
复制标题
DOI：
10.1056/nejm199910073411510
复制
发表时间：
1999-10-07
影响因子：
158.5
通讯作者：
Vogelstein, B
中科院分区：
文献类型：
--
作者：
Zhou, SB;Kinzler, KW;Vogelstein, B
在过去的一年里，几项对基因操纵的smadgenes小鼠的研究引起了癌症研究人员的注意。Smad1是一个至少有9个基因的家族，每个基因都有一个识别号（例如Smad1、Smad2和smad9），每个基因都编码一种蛋白质，参与介导细胞对转化生长因子β (TGF-β)和相关多肽的反应。这个配体家族的原型被命名为“转化生长因子”，因为它最初被确定为一种刺激成纤维细胞肿瘤样行为的血清成分。现在我们知道它在…的生死中起着重要的作用。
In the past year, several studies of mice with genetically manipulatedSmadgenes have caught the attention of cancer researchers.Smadis a family of at least nine genes, each bearing an identifying number (e.g.,Smad1, Smad2,andSmad9), and each encoding a protein involved in mediating cellular responses to transforming growth factor β (TGF-β) and related polypeptides. The prototype for this family of ligands was named “transforming growth factor” because it was initially identified as a serum component that stimulated neoplastic-like behavior in fibroblasts. Now we know that it has important roles in the life and death of . . .