Chemotherapeutic activity of L-histidinol against spontaneous, autochthonous murine breast tumors.
Chemotherapeutic activity of L-histidinol against spontaneous, autochthonous murine breast tumors.
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L-组氨醇对自发性、本土小鼠乳腺肿瘤的化疗活性。
DOI：
10.1159/000238801
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发表时间：
1990
期刊：
影响因子：
3.3
通讯作者：
Martin,DS
中科院分区：
文献类型：
--
作者：
Stolfi,RL;Martin,DS
在旨在研究5-氟尿嘧啶(Fura)Byl-Histidinol对CD8FI乳腺肿瘤抑制作用的生化基础的实验中，发现L-Histidinol抑制这些肿瘤的RNA和DNA合成。这一发现提示，L-组氨醇可能在CD8FI乳腺肿瘤中具有抗增殖活性，并在此基础上，我们在体内评价了不同给药方案的抗肿瘤活性。本报告描述了L-组氨醇的给药方案，在可耐受的剂量下，该方案对自发的、固有的CD8FI乳腺肿瘤产生了显著的活性。据我们所知，以前还没有关于L-组氨醇作为单一药物给药的体内抗肿瘤活性的报道。
In experiments designed to investigate the biochemical basis for the diminution of the antitumor activity of 5-fluorouracil (FUra) byL-histidinol in CD8FI breast tumors, it was discovered thatL-histidinol inhibits RNA and DNA synthesis in these tumors. This finding suggested the possibility thatL-histidinol might have antiproliferative activity in the CD8FI breast tumor, and on that basis we evaluated different administration schedules ofL-histidinol for antitumor activity in vivo. The present report describes a schedule ofL-histidinol administration which yielded significant activity against spontaneous, autochthonous CD8FI breast tumors consistently at tolerable doses. To our knowledge, there are no previous reports of in vivo antitumor activity associated with the administration ofL-histidinol as a single agent.