Thymine hydroperoxide as a mediator in ionising radiation mutagenesis

Thymine hydroperoxide as a mediator in ionising radiation mutagenesis
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胸腺嘧啶氢过氧化物作为电离辐射诱变介质

DOI:
10.1038/259341a0
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发表时间:
1976
期刊:
影响因子:
64.8
通讯作者:
S. Y. Wang
S. Y. Wang
中科院分区:
综合性期刊1区
文献类型:
--
作者:
H. Thomas;R. M. Herriott;B. Hahn;S. Y. Wang

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我们描述了化学合成的cis-5,6-dihydro-6-hydroperoxy-5-hydroxythymine(6-TOOH)1对流感嗜血杆菌2,3转化DNA的诱变作用,并提出了电离辐射在体内诱导突变的机制。
WE describe the mutagenic action of chemically synthesised cis-5,6-dihydro-6-hydroperoxy-5-hydroxythymine (6-TOOH)1 on transforming DNA of Haemophilus influenzae2,3, and suggest a mechanism by which ionising radiation induces mutations in vivo.