EFFECT OF PARENCHYMA AND LENGTH CHANGES ON VESSEL PRESSURE-DIAMETER BEHAVIOR IN PIG LUNGS
EFFECT OF PARENCHYMA AND LENGTH CHANGES ON VESSEL PRESSURE-DIAMETER BEHAVIOR IN PIG LUNGS
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DOI：
10.1152/jappl.1979.47.4.666
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发表时间：
1979-01-01
影响因子：
3.3
通讯作者：
HYATT, RE
中科院分区：
文献类型：
--
作者：
LAIFOOK, SJ;HYATT, RE
在不同的经肺压力(PTP)下，将猪肺实质内最大动脉段的压力-直径(PD)行为与其从实质中切除并延伸到与完整状态相当的长度后的行为进行了比较。对于长度的生理性变化，在PTP从4到25cmH2O变化期间，肺充气可能会发生这种情况，切除的血管直径在恒定的跨壁压力下没有显著变化。当PTP为4cmH2O时，切除血管的PD行为与完整血管的PD行为没有显著差异。在任何恒定的动脉压下，完整的血管直径随着PTP的增加而增大。通过直接比较完整血管和切除血管的PD曲线得到的血管周围压(Px)的估计值如下：Px等于PTP时的胸膜压力，接近功能残存容量。随着PTP的增加，Px几乎呈线性下降。Px随动脉压下降而降低。这些结果与血管周围间质流体压力的直接测量是一致的。
At several transpulmonary pressures (Ptp), the pressure-diameter (PD) behavior of the largest intraparenchymal arterial segment in the isolated pig lung was compared with the behavior of the segment after its excision from the parenchyma and its extension to lengths equivalent to those in the intact state. For physiological changes in length, as may occur with lung inflation during Ptp changes from 4 to 25 cmH2O, excised-vessel diameters did not change significantly at a constant transmural pressure. The excised-vessel PD behavior was not significantly different from the intact-vessel PD behavior at a Ptp of 4 cmH2O. At any constant arterial pressure, intact-vessel diameters became larger as Ptp increased. Estimates of the perivascular pressure (Px) obtained by directly comparing intact-vessel and excised-vessel PD curves were as follows: Px was equal to pleural pressure at a Ptp approximating the functional residual capacity. Px decreased almost linearly as Ptp increased. Px decreased with a fall in arterial pressure. These results are consistent with direct measurements of the perivascular interstitial fluid pressure.