EFFECTS OF DIETARY GOSSYPOL ON ANIMALS
EFFECTS OF DIETARY GOSSYPOL ON ANIMALS
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DOI：
10.1007/bf02632963
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发表时间：
1970-01-01
影响因子：
2
通讯作者：
CLAWSON, AJ
中科院分区：
文献类型：
--
作者：
SMITH, FH;CLAWSON, AJ
介绍了棉酚对动物的病理作用以及蛋白质的质和量对其毒性的影响。本文介绍了从棉酚中毒猪肝脏中分离棉酚的方法及其鉴定。通过测定游离棉酚和结合棉酚在猪各器官中的含量，表明棉酚在猪体内分布广泛。研究了克服毒性和降低其在猪体内积累所需的铁水平。本文研究了铜、锌、锰、铁单独和联合应用对大鼠增重和肝棉酚蓄积的影响。铁绝对是最有效的解毒剂。
The pathological effects of gossypol in animals and the effects of protein quality and quantity on its toxicity are described. The method used for the isolation of gossypol from the liver of gossypol‐intoxicated pigs and its identification are presented. Wide distribution of gossypol in swine is shown by determining the free and bound gossypol in the various organs. The levels of iron necessary to overcome toxicity and to lower its accumulation in pigs were investigated. Effects of copper, zinc, manganese and iron, alone and in combination, on the gains and the accumulation of gossypol in the liver of rats were studied. Iron was definitely the most effective detoxifying agent.