Serum lipids and tissue DNA content in Egyptian female breast cancer patients
Serum lipids and tissue DNA content in Egyptian female breast cancer patients
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DOI：
10.1093/jjco/hyg059
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发表时间：
2003-06-01
影响因子：
2.4
通讯作者：
El-Aaser, AA
中科院分区：
文献类型：
--
作者：
Abu-Bedair, FA;El-Gamal, BA;El-Aaser, AA
背景：一些临床研究表明，血脂水平和组织DNA含量对乳腺癌的预后有重要意义。在调查埃及女性乳腺癌患者生物学特征的过程中，我们检测了绝经前和绝经后乳腺癌患者的血脂水平和组织DNA含量。方法：检测乳腺癌患者血清中总脂肪、总胆固醇和甘油三酯的水平，并与对照组进行比较。结果：绝经前(卵泡和黄体)和绝经后乳腺癌患者的总脂水平均显著升高。绝经前(卵泡和黄体)患者的总胆固醇水平显著升高，而绝经后妇女的总胆固醇水平无明显变化。绝经后妇女的甘油三酯水平显著升高，而绝经前妇女的甘油三酯水平没有显著差异。无论是卵泡期还是黄体期，绝经前患者的肿瘤DNA含量均高于绝经后患者。III级乳腺癌组织DNA含量显著高于I级和II级乳腺癌组织。结论：绝经前乳腺癌患者血清、总脂和总胆固醇水平升高与乳腺癌风险增加有关。绝经后妇女的高总血脂和甘油三酯水平也与此有关。乳腺癌组织中的DNA含量可能有助于根据恶性程度确定适合个别病例的治疗方案。
Background: Several clinical studies suggest the prognostic significance of serum lipid levels and tissue DNA content in breast cancer. In the course of investigating the biological features of this disease among Egyptian female patients, we examined the serum lipid levels and tissue DNA content of premenopausal and postmenopausal breast cancer patients.Methods: Levels of total lipid, total cholesterol, and triglycerides were measured in the sera of women with breast cancer and compared with those of the control women. The DNA content in breast cancer tissue was also measured in these patients.Results: Total lipid levels showed a significant increase in both premenopausal (follicular and luteal) and postmenopausal patients. Total cholesterol levels significantly increased in premenopausal (follicular and luteal) patients with no significant change in postmenopausal women. Triglyceride levels showed a significant increase in postmenopausal women, whereas no significant differences were observed in premenopausal patients. Tumors of premenopausal patients, in both follicular and luteal phases, showed a higher DNA content as compared with those of postmenopausal patients. Breast cancer tissues of grade III showed significantly higher DNA content than those of grade I and grade II.Conclusions: This study suggests an association between high levels of serum, total lipid and total cholesterol, and increased breast cancer risk in premenopausal women. Such an association is also suggested for the high total serum lipid and triglyceride levels in postmenopausal women. The DNA content in breast cancer tissue might be useful in determining a suitable therapy for individual cases, based on the malignancy grade.