Dual functions of β-amyloid oligomer and fibril in Cu(II)-induced H2O2 production
Dual functions of β-amyloid oligomer and fibril in Cu(II)-induced H2O2 production
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DOI：
10.1016/j.regpep.2010.05.001
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发表时间：
2010-08-09
影响因子：
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通讯作者：
Li, Yan-Mei
中科院分区：
文献类型：
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作者：
Fang, Chuan-Lin;Wu, Wei-Hui;Li, Yan-Mei
β-淀粉样蛋白（A β）聚集和Cu（II）相关的氧化应激参与阿尔茨海默病（AD）神经元的功能障碍和死亡。A β的促氧化剂或抗氧化剂性质也存在很大的争议。这里A β 42在其单体中的H2 O2产生能力，在Cu（II）存在下研究了低聚物和纤维状形式。结果表明，低聚物和纤维状形式的A β 42在较低浓度的Cu（II）下都可以促进H2 O2的产生。而A β 42寡聚体能在更大程度上促进H2 O2的产生。当Cu（II）浓度增加时，A β 42寡聚体和原纤维的促进作用可转化为抑制作用。这表明A β 42寡聚体和原纤维在Cu（II）诱导的H2 O2产生中的双重功能。据此，我们对A β 42在Cu（II）介导的氧化应激中的作用提出了新的观点，并为A β 42寡聚体可能是AD发病机制的主要原因的观点提供了新的证据（C）2010 Elsevier B.V版权所有
Amyloid-beta (A beta) aggregation and Cu(II)-related oxidative stress are involved in the dysfunction and death of neurons in Alzheimer's disease (AD) However, the relationship between A beta and Cu(II) is not clear Furthermore. the pro- or anti-oxidant properties of A beta are also under great debate Here the H2O2 generating ability of A beta 42 in its monomeric, oligomeric and fibrillar forms was studied in the presence of Cu(II) The results show that A beta 42 in both oligomeric and fibrillar forms can promote H2O2 generation at lower concentrations of Cu(II) and A beta 42 oligomer can promote H2O2 generation to a higher extent Nevertheless. the promoting effect of A beta 42 oligomer and fibril may convert to an inhibitory effect when the concentration of Cu(II) is increased. This indicates the dual functions of A beta 42 oligomer and fibril in Cu(II)-induced H2O2 production Hereby we present a new perspective on the roles of A beta 42 in Cu(II)-mediated oxidative stress and add new evidence to the viewpoint that A beta 42 oligomer may be primarily responsible for the pathogenesis of AD (C) 2010 Elsevier B.V All rights reserved