Millisecond-Timescale Local Network Coding in the Rat Primary Somatosensory Cortex
Millisecond-Timescale Local Network Coding in the Rat Primary Somatosensory Cortex
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DOI：
10.1371/journal.pone.0021649
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发表时间：
2011-06-29
期刊：
影响因子：
3.7
通讯作者：
Oweiss, Karim G.
中科院分区：
文献类型：
--
作者：
Eldawlatly, Seif;Oweiss, Karim G.
新皮层神经元之间的关联被认为在介导外部刺激的感觉处理中起着不可或缺的作用。在这种相关性中，时间精确度的作用被假设为增强了沿着感觉通路的信息流。然而，它在这些途径输出端介导信息整合方面的作用仍然知之甚少。在这里，我们研究了在单侧胡须刺激过程中，同时记录的第V层神经元之间的尖峰时间相关性和跨列的麻醉大鼠的初级躯体感觉皮层。我们使用贝叶斯统计和信息理论来量化记录的细胞之间的因果关系的影响与毫秒精度。对于每一个受刺激的胡须，我们在多次重复试验中推断出稳定的、特定于胡须的、动态的贝叶斯网络，胡须内的网络相似性为83.3 +/- 6%，而胡须间的网络相似性仅为50.3 +/- 18%。这些网络进一步提供了关于须状物身份的信息，该信息比由第一尖峰的潜伏期提供的信息高约6倍，比由单独检查的单个神经元的尖峰计数提供的信息高13倍。此外，预测个别神经元的精确发射条件下的知识推定的突触前细胞放电是3倍以上的预测条件下的刺激开始。两者合计，这些结果表明，存在一个时间精确的网络编码机制，整合了关于触须位置和搅拌动力学的V层内的相邻列的信息，以介导由V层支配的运动区的晶须运动。
Correlation among neocortical neurons is thought to play an indispensable role in mediating sensory processing of external stimuli. The role of temporal precision in this correlation has been hypothesized to enhance information flow along sensory pathways. Its role in mediating the integration of information at the output of these pathways, however, remains poorly understood. Here, we examined spike timing correlation between simultaneously recorded layer V neurons within and across columns of the primary somatosensory cortex of anesthetized rats during unilateral whisker stimulation. We used Bayesian statistics and information theory to quantify the causal influence between the recorded cells with millisecond precision. For each stimulated whisker, we inferred stable, whisker-specific, dynamic Bayesian networks over many repeated trials, with network similarity of 83.3 +/- 6% within whisker, compared to only 50.3 +/- 18% across whiskers. These networks further provided information about whisker identity that was approximately 6 times higher than what was provided by the latency to first spike and 13 times higher than what was provided by the spike count of individual neurons examined separately. Furthermore, prediction of individual neurons' precise firing conditioned on knowledge of putative pre-synaptic cell firing was 3 times higher than predictions conditioned on stimulus onset alone. Taken together, these results suggest the presence of a temporally precise network coding mechanism that integrates information across neighboring columns within layer V about vibrissa position and whisking kinetics to mediate whisker movement by motor areas innervated by layer V.