Heterogeneity of Multipotent Mesenchymal Stromal Cells: From Stromal Cells to Stem Cells and Vice Versa
Heterogeneity of Multipotent Mesenchymal Stromal Cells: From Stromal Cells to Stem Cells and Vice Versa
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DOI：
10.1097/tp.0b013e3181a283ee
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发表时间：
2009-05-15
期刊：
影响因子：
6.2
通讯作者：
Horwitz, Edwin M.
中科院分区：
文献类型：
--
作者：
Dominici, Massimo;Paolucci, Paolo;Horwitz, Edwin M.
40多年前发现的多能间充质基质细胞（MSC）的生物学特征首先与造血干细胞（HSC）进行了逐步比较，最近又与胚胎干细胞（ESC）进行了比较。虽然这些比较对于帮助澄清其性质至关重要，但现在有大量数据表明，MSC在体外代表了一组独立和异质的祖细胞，具有独特的自我更新特性和既定的分化潜力。然而，在人类和动物中的研究进展已经逐步揭示了MSC在体内可能面临的限制。认识到这些问题并挑战MSC的严厉似乎是一种倒退。尽管如此，它也可能代表了一个阶段的开始，在这个阶段中，新型临床前方法的引入可以为影响细胞植入和存活的体内因素提供更好的表征和标准化，从而使间充质祖细胞在多种临床环境中产生更成功的影响。
Discovered more than 40 years ago, the biological features of multipotent mesenchymal stromal cells (MSC) were progressively compared first with hematopoietic stem cells (HSC) and, more recently, with embryonic stem cells (ESC). Although these comparisons have been crucial in helping to clarify their nature, there is now a robust amount of data indicating that MSC in vitro represent an independent and heterogeneous group of progenitors with distinct self-renewal properties and established differentiation potentials. However, research developments both in humans and animals have progressively revealed the limits that MSC may face in vivo. To recognize these issues and challenge MSC sternness may seem to be a step backward. Nevertheless, it might also represent the beginning of a phase in which the introduction of novel preclinical approaches could provide better characterization and standardization of the in vivo factors influencing cell engraftment and survival, allowing a more successful impact of mesenchymal progenitors in several clinical settings.