COVID-19-associated acute kidney injury: consensus report of the 25th Acute Disease Quality Initiative (ADQI) Workgroup.
COVID-19-associated acute kidney injury: consensus report of the 25th Acute Disease Quality Initiative (ADQI) Workgroup.
复制标题
COVID-19与19号相关的急性肾脏损伤：第25次急性疾病质量倡议（ADQI）工作组的共识报告。
DOI：
10.1038/s41581-020-00356-5
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发表时间：
2020-12
期刊：
影响因子：
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通讯作者：
Kellum JA
中科院分区：
文献类型：
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作者：
Nadim MK;Forni LG;Mehta RL;Connor MJ Jr;Liu KD;Ostermann M;Rimmelé T;Zarbock A;Bell S;Bihorac A;Cantaluppi V;Hoste E;Husain-Syed F;Germain MJ;Goldstein SL;Gupta S;Joannidis M;Kashani K;Koyner JL;Legrand M;Lumlertgul N;Mohan S;Pannu N;Peng Z;Perez-Fernandez XL;Pickkers P;Prowle J;Reis T;Srisawat N;Tolwani A;Vijayan A;Villa G;Yang L;Ronco C;Kellum JA
2019冠状病毒病（COVID-19）患者肾脏受累很常见，其范围从蛋白尿和血尿到需要肾脏替代治疗（RRT，也称为肾脏替代治疗）的急性肾损伤（AKI）。COVID-19相关AKI （COVID-19 AKI）与高死亡率相关，是COVID-19患者院内全因死亡的独立危险因素。COVID-19患者AKI的病理生理和机制尚未完全阐明，似乎是多因素的，与其他危重患者AKI的病理生理一致。对于COVID-19 AKI的预防和管理知之甚少。COVID-19病例出现区域性“激增”可能会限制医院资源，包括透析的可用性和供应；因此，需要每天仔细评估现有资源。在本共识声明中，急性疾病质量倡议根据当前文献为COVID-19 AKI的诊断、预防和管理提供了建议。我们还对未来的研究领域提出了建议，旨在提高对COVID-19 AKI患者潜在过程的理解并改善其预后。COVID-19相关AKI （COVID-19 AKI）与高死亡率相关，是COVID-19患者院内全因死亡的独立危险因素。这份来自急性疾病质量倡议的共识声明为COVID-19 AKI的诊断、预防和管理以及未来的研究领域提供了建议，旨在提高对COVID-19 AKI患者潜在过程和结果的理解。
Kidney involvement in patients with coronavirus disease 2019 (COVID-19) is common, and can range from the presence of proteinuria and haematuria to acute kidney injury (AKI) requiring renal replacement therapy (RRT; also known as kidney replacement therapy). COVID-19-associated AKI (COVID-19 AKI) is associated with high mortality and serves as an independent risk factor for all-cause in-hospital death in patients with COVID-19. The pathophysiology and mechanisms of AKI in patients with COVID-19 have not been fully elucidated and seem to be multifactorial, in keeping with the pathophysiology of AKI in other patients who are critically ill. Little is known about the prevention and management of COVID-19 AKI. The emergence of regional ‘surges’ in COVID-19 cases can limit hospital resources, including dialysis availability and supplies; thus, careful daily assessment of available resources is needed. In this Consensus Statement, the Acute Disease Quality Initiative provides recommendations for the diagnosis, prevention and management of COVID-19 AKI based on current literature. We also make recommendations for areas of future research, which are aimed at improving understanding of the underlying processes and improving outcomes for patients with COVID-19 AKI. COVID-19-associated AKI (COVID-19 AKI) is associated with high mortality and is an independent risk factor for all-cause in-hospital death in patients with COVID-19. This Consensus Statement from the Acute Disease Quality Initiative provides recommendations for the diagnosis, prevention and management of COVID-19 AKI and for areas of future research, with the aim of improving understanding of the underlying processes and outcomes for patients with COVID-19 AKI.