The molecular architecture of neuronal kinase/phosphatase signalling complexes.
The molecular architecture of neuronal kinase/phosphatase signalling complexes.
复制标题
神经元激酶/磷酸酶信号复合物的分子结构。
DOI：
10.1042/bst0270539
复制
发表时间：
1999
影响因子：
3.9
通讯作者：
Scott,JD
中科院分区：
文献类型：
--
作者：
Tavalin,SJ;Westphal,RS;Colledge,M;Langeberg,LK;Scott,JD
The transduction of extracellular signals across the postsynaptic membrane to appropriate subneuronal targets is a tightly regulated process that underlies diverse physiological functions [11. As many signalling enzymes are widely distributed and often have rather broad substrate specificities, a critical element in signal transduction is the control of specificity. How does an individual neurotransmitter direct the correct pool of second messengers to particular downstream enzymes, and in turn, how does each enzyme find its appropriate set of protein substrates? In some cases, specificity is achieved by enzymes that have limited or precise substrate recognition. However, recent evidence suggests that subcellular targeting through association with scaffold adapter and
