Is sexual transmission an important pattern for herpes simplex type 2 virus seroconversion in the Spanish general population?
Is sexual transmission an important pattern for herpes simplex type 2 virus seroconversion in the Spanish general population?
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性传播是西班牙普通人群中 2 型单纯疱疹病毒血清转化的重要模式吗？
DOI：
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发表时间：
1999
影响因子：
12.7
通讯作者：
J. García‐de‐Lomas
中科院分区：
文献类型：
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作者：
P. García;R. Dal;L. Aguilar;J. Granizo;J. García‐de‐Lomas
社区内 2 型单纯疱疹 (HSV-2) 血清流行率由母亲向婴儿的性传播和围产期传播决定，这是病毒传播的两个主要来源。对西班牙人群的代表性样本（n = 3974）进行了 HSV-2 血清流行病学研究，以间接评估这两种传播途径的相对相关性。样本包括 1922 名男性和 2052 名女性，年龄范围为 5-59 岁，按性别和年龄（5-12、13-19、20-29、30-39、40-49 和 50-59 岁）分层。通过基于重组糖蛋白 G2 (gG2) 的酶联免疫吸附测定，筛选血清中的 HSV-2 特异性 Ig G 抗体。 HSV-2 抗体的总体患病率为 3.6%（95% CI：3.1-4.2%）。不同性别的患病率没有差异：男性（3.6%；95% CI：2.8-4.6%）和女性（3.6%；95% CI：2.8-4.5%）。各年龄组之间的血清阳性率没有显着差异。 HSV-2 抗体的检测与年龄增长无关，正如对性传播疾病的预期一样。不同年龄组之间的血清阳性率没有差异这一事实表明，该病毒并未在普通人群中传播，可能仅限于高危人群。在育龄女性群体和最年轻人群中发现的相似阳性率表明，围产期病毒脱落是西班牙人群中 HSV-2 血清转化的主要来源。 J. Med。病毒。 59:194–197, 1999。© 1999 Wiley-Liss, Inc.
Herpes simplex type 2 (HSV‐2) seroprevalence within a community is determined by sexual and perinatal transmission from mother to baby, the two main sources of virus shedding. A seroepidemiological study of HSV‐2 was undertaken on a representative sample (n = 3974) of the Spanish population to assess indirectly the relative relevance of these two transmisssion routes. The sample comprised 1922 men and 2052 women in the age range 5–59 years, stratified by sex and age (5–12, 13–19, 20–29, 30–39, 40–49, and 50–59 years). Sera were screened for HSV‐2 specific Ig G antibodies by an enzyme‐linked immunoabsorbent assay based on recombinant glycoprotein G2 (gG2). The overall prevalence of antibodies to HSV‐2 was 3.6% (95% CI: 3.1–4.2%). Prevalence by gender did not differ: males (3.6%; 95% CI: 2.8–4.6%) and females (3.6%; 95% CI: 2.8–4.5%). There were no significant differences between age groups with respect to seropositivity rates. Detection of HSV‐2 antibodies was not associated with increasing age, as is expected for a sexually transmitted disease. The fact that seroprevalence rates among the different age groups did not differ suggests that the virus is not circulating in the general population and may be restricted to risk groups only. Similar positivity rates found in the group of females of childbearing age and in the youngest population indicate that perinatal viral shedding is the main source of HSV‐2 seroconversion in the Spanish population. J. Med. Virol. 59:194–197, 1999. © 1999 Wiley‐Liss, Inc.
影响因子：
158.5
作者：
WALD, A;ZEH, J;COREY, L
通讯作者：
COREY, L
影响因子：
158.5
作者：
COREY, L;SPEAR, PG
通讯作者：
SPEAR, PG