Clinical manifestations of COVID-19 in patients with asthma, hypertension, and diabetes mellitus.
Clinical manifestations of COVID-19 in patients with asthma, hypertension, and diabetes mellitus.
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DOI：
10.25122/jml-2021-0364
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发表时间：
2022-12
影响因子：
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通讯作者：
Miftahussurur, Muhammad
中科院分区：
文献类型：
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作者：
Budiarti, Retno;Ediono, Ediono;Kalaznykov, Mohammad;Yamaoka, Yoshio;Miftahussurur, Muhammad
新冠肺炎感染的临床症状因人而异，需要不同的处理。本研究旨在探讨新冠肺炎在哮喘、高血压和糖尿病患者中的临床表现。我们分析了540例新冠肺炎确诊为哮喘、高血压和糖尿病等并存疾病的患者的医疗记录数据，观察入院时的生命体征、胸部X光和实验室结果。患者多为男性(57.0%)。最常见的共病是高血压(46.3%)和糖尿病(46.3%)，其次是哮喘(7.4%)。病情好转273例(50.6%)。高血压患者的住院时间最长(13.0±8.5天)。血氧饱和度和呼吸频率三组间差异有统计学意义(p=0.002，p<；0.0001)。三组患者的平均淋巴细胞数(p=0.028)和红细胞压积(p=0.001)差异有统计学意义，高血压组的平均淋巴细胞数(15.1±8.9)和红细胞压积(38.7±6.9)最高。新冠肺炎对哮喘、高血压和糖尿病患者的最终病情、住院时间、血氧饱和度和呼吸频率以及血液学水平(主要是淋巴细胞和红细胞压积)都有显著影响。治疗、年龄和感染可能是每种类型合并症不同结果的决定性因素。
The clinical symptoms of COVID-19 infection differ from one patient to another, requiring different management. This study intended to characterize the clinical manifestation of COVID-19 in patients with asthma, hypertension, and diabetes mellitus (DM). We analyzed data from 540 medical records of patients with comorbidities like asthma, hypertension, and DM diagnosed with COVID-19, looking at vital signs upon admission, chest X-ray, and laboratory results. Most patients were male (57.0%). The most prevalent comorbidity was hypertension (46.3%) and DM (46.3%), followed by asthma (7.4%). 273 patients had improved condition (50.6%). Patients with hypertension had the most extended length of stay compared to other comorbidities groups (13.0±8.5 days). There were significant differences in the oxygen saturation and respiration rate between the three groups (p=0.002, p<0.0001, respectively). The mean lymphocyte (p=0.028) and hematocrit count (p=0.001) were significantly different between the three comorbid groups, with the hypertension group having the highest mean lymphocyte (15.1±8.9) and hematocrit (38.7±6.9) count. COVID-19 had a significant impact on patients with asthma, hypertension, and diabetes comorbidities concerning the final condition, length of stay, oxygen saturation, and respiratory rate, and also on the hematology level, mainly lymphocyte and hematocrit. Treatment, age, and infection might be determinant factors for different outcomes in each type of comorbidity.