Epidemiology of Diet and Melanoma-Letter.
Epidemiology of Diet and Melanoma-Letter.
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饮食和黑色素瘤流行病学信。
DOI：
10.1158/1055-9965.epi-18-0882
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Cho,Eunyoung
中科院分区：
文献类型：
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作者：
Dhana,Ashar;Yen,Hsi;Qureshi,AbrarA;Cho,Eunyoung
在最近的一篇综述中，Yang和同事总结了饮食和黑色素瘤的流行病学研究(1)。鉴于全球黑色素瘤发病率的上升，我们感谢作者引起对这一主题的关注。我们想补充一些关于叶酸和黑色素瘤之间关系的观察结果。作者描述了13项随机对照试验的荟萃分析，发现叶酸补充与黑色素瘤风险之间没有关联(2)。然而，结果应谨慎解释，因为纳入的黑色素瘤病例很少（n= 126），随访时间相对较短（平均试验时间为5.2年）。作者描述了另一项对3项试验的荟萃分析，发现叶酸补充剂与黑色素瘤风险呈负相关(3)。然而，更少的黑色素瘤病例（n= 38）被纳入，所有三项研究都被纳入前荟萃分析(2)。因此，虽然这两项荟萃分析发表在同一年，结果不同，但更大的荟萃分析可能更适合解释(2)。作者还提到了一项来自法国的前瞻性队列研究，该研究报告了饮食中叶酸摄入量与总体皮肤癌风险之间的正相关(顶层与底层的HR，
In a recent review, Yang and colleagues summarized epidemiologic studies on diet and melanoma (1). We thank the authors for drawing attention to this topic given the rising incidence of melanoma worldwide. We would like to add several observations regarding the relationship between folate/folic acid and melanoma.The authors described a meta-analysis of 13 randomized controlled trials, which found no association between folic acid supplementation and melanoma risk (2). However, the results should be interpreted with caution, because few melanoma cases (n= 126) were included and follow-up was relatively short (mean trial duration was 5.2 years). The authors described another meta-analysis of 3 trials, which found an inverse association between folic acid supplementation and melanoma risk (3). However, even fewer melanoma cases (n= 38) were included, and all three studies were included in the former meta-analysis (2). Therefore, although these two meta-analyses were published in the same year with different results, the larger meta-analysis may be more appropriate for interpretation (2). The authors also mentioned a prospective cohort study from France that reported a positive association between dietary folate intake and overall skin cancer risk (HR for top vs. bottom tertile,