Atriopeptins: renal-specific vasodilators in conscious dogs.
Atriopeptins: renal-specific vasodilators in conscious dogs.
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Atriopeptins：清醒狗的肾脏特异性血管扩张剂。
DOI：
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发表时间：
1985
影响因子：
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通讯作者：
P. Needleman
中科院分区：
文献类型：
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作者：
T. Hintze;M. Currie;P. Needleman
用清醒的狗研究心房肽（I、II、III）对肾脏、髂动脉、肠系膜和冠状动脉血流的影响。静脉注射心房肽II和III引起肾血流量的剂量相关性增加，而心房肽I没有影响。心房肽II和III在5 μ g/kg时使肾血流量从252 +/- 29 ml/min增加27 +/- 5.0%，从238 +/- 32 ml/min增加18 +/- 2.9%，并使肾血管阻力从0.431 +/- 0.048 mmHg X ml-1 X min减少24 +/- 3.2%，从15.1 +/- 1.2%减少24 +/- 3.2%。从0.443 +/- 0.023 mmHg X ml-1 X min。心房肽I、II或III对全身动脉压、心率、冠状动脉、肠系膜或髂动脉血流无显著影响。硝酸甘油（25 μ g/kg）可增加肾血流量（28 +/- 5.0%）至与心房肽II和III相当的程度，也可引起冠状动脉、髂动脉和肠系膜血流量增加，并引起全身血压福尔斯下降和反射性心动过速。因此，在清醒的狗，心房肽II和III是有效的选择性肾血管扩张剂，不表现出全身血流动力学效应相比，硝酸甘油，非选择性血管扩张剂。在这些肽的羧基末端裂解产生心房肽I，完全消除了肾血管舒张作用。
Conscious dogs were instrumented to study the effects of atriopeptins (I, II, III) on renal, iliac, mesenteric, and coronary blood flow. Intravenous injection of atriopeptins II and III caused a dose-related increase in renal blood flow, whereas atriopeptin I had no effect. Atriopeptins II and III at 5 micrograms/kg increased renal blood flow 27 +/- 5.0% from 252 +/- 29 ml/min and 18 +/- 2.9% from 238 +/- 32 ml/min and reduced renal vascular resistance 24 +/- 3.2% from 0.431 +/- 0.048 mmHg X ml-1 X min and 15.1 +/- 1.2% from 0.443 +/- 0.023 mmHg X ml-1 X min, respectively. Atriopeptin I, II, or III exerted no significant effect on systemic arterial pressure, heart rate, coronary, mesenteric, or iliac blood flows. Doses of nitroglycerin (25 micrograms/kg) that increased renal blood flow (28 +/- 5.0%) to a degree comparable to atriopeptins II and III also caused increases in coronary, iliac, and mesenteric blood flows and produced falls in systemic blood pressure and a reflex tachycardia. Thus in the conscious dog, atriopeptins II and III are potent selective renal vasodilators that do not exhibit systemic hemodynamic effects in contrast to nitroglycerin, a nonselective vasodilator. Cleavage at the carboxy terminal end of these peptides to yield atriopeptin I abolishes the renal vasodilator action entirely.