[A population-based matched case-control study on the risk factors of gastric cardia cancer].
[A population-based matched case-control study on the risk factors of gastric cardia cancer].
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DOI：
10.3760/cma.j.issn.0253-3766.2011.10.011
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发表时间：
2011-10
期刊：
影响因子：
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通讯作者：
De-li Zhao;Wanqing Chen;Ting-ting Yu;Yu-tong He;Zhi-feng Chen;D. Wen;Xibin Sun;Li-na Wang
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文献类型：
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作者：
De-li Zhao;Wanqing Chen;Ting-ting Yu;Yu-tong He;Zhi-feng Chen;D. Wen;Xibin Sun;Li-na Wang
目的探讨贲门癌的主要危险因素。方法选择河北省磁县、涉县、河南省临县、山东省肥城市和辽宁省庄河市5个食管癌、胃癌高发区，建立肿瘤登记制度。从每个癌症登记数据库中选择2008年1月1日以后新诊断的50例贲门癌病例。使用了一份经专家充分协商的统一调查表。在这些地区进行了以人群为基础的1：3病例对照研究。采用统一的调查表对250例贲门癌患者和750例正常对照进行调查。数据采用拟合条件Logistic分析进行统计分析。结果吸烟、被动吸烟、饮酒、饮食不规律、就餐姿势不当、重口味、干制食品、腌制食品、油炸食品、辛辣食品、胃肠道病史、胃食管反流病（GERD）等均可增加贲门癌的发病风险。单因素Logistic回归分析显示，多吃豆类、高BMI是保护因素。胃肠道病史（OR = 42.899），干制食品（OR = 5.932），饮食不规律（OR = 4.911），热食（OR = 4.144），腌制食品（OR = 3.287），被动吸烟多吃豆类（OR = 0.254）和BMI ≥ 25（OR = 0.492）为保护因素。结论贲门癌是由环境危险因素和遗传因素共同作用的结果。在贲门癌高发区开展健康教育，将一级预防普及到人们的日常生活中，将有利于降低贲门癌的发病率。
OBJECTIVE To find the major risk factors associated with gastric cardia cancer. METHODS We selected five high incidence areas of esophageal cancer and gastric cancer which have cancer registration system, i.e. Cixian and Shexian of Hebei Province, Linxian of Henan Province, Feicheng of Shandong Province and Zhuanghe of Liaoning Province. Fifty newly diagnosed cases of cardiac cancer after January 1, 2008 were selected from each cancer registration database. A uniform questionnaire, which was fully consulted by experts, was used. Population-based 1:3 case-control study was conducted in those areas. The study recruited 250 cases of cardiac cancer and 750 matched controls, which were investigated with the uniform questionnaire. The data were statistically analyzed by fitting-conditional Logistic analysis. RESULTS Smoking, passive smoking, alcohol drinking, irregular meal, improper dining posture, heavy taste, dried food, pickled food, fried food, hot food, gastrointestinal history, gastroesophageal reflux disease (GERD) can increase the risk of cardiac cancer. To eat more bean and high BMI are protective factors of the single factor logistic analysis. Gastrointestinal history (OR = 42.899), dried food (OR = 5.932), irregular meal (OR = 4.911), hot food (OR = 4.144), pickled food (OR = 3.287), passive smoking (OR = 2.355), and GERD (OR = 1.930) can increase the risk of cardiac cancer, eat more bean (OR = 0.254) and BMI ≥ 25 (OR = 0.492) are protective factors of the mixture factors logistic analysis. CONCLUSIONS Gastric cardia cancer is caused by environmental risk factors and genetic factors. Health education in high cardiac cancer incidence areas and primary prevention popularized into people's daily life will be beneficial to decreasing the incidence of gastric cardia cancer.