Metabolic syndrome and autoimmune diabetes: action LADA 3.
Metabolic syndrome and autoimmune diabetes: action LADA 3.
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DOI：
10.2337/dc08-1419
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发表时间：
2009-01
期刊：
影响因子：
16.2
通讯作者：
Leslie, Richard David G.
中科院分区：
文献类型：
--
作者：
Hawa, Mohammed I.;Thivolet, Charles;Mauricio, Didac;Alemanno, Irene;Cipponeri, Elisa;Collier, David;Hunter, Steven;Buzzetti, Raffaella;de Leiva, Alberto;Pozzilli, Paolo;Leslie, Richard David G.
本研究的目的是评估欧洲成年糖尿病患者代谢综合征的患病率是否与糖尿病类型相关。研究设计和方法--作为LADA行动研究的一部分，对连续系列的糖尿病门诊患者进行代谢综合征的频率评估，并与人群对照组进行比较。总计2，011名受试者年龄30-70岁，包括1,247例无谷氨酸脱羧酶自身抗体（GADA）的新发2型糖尿病患者，117例确诊后至少6个月未接受胰岛素治疗的GADA非胰岛素需要患者（称为成人隐匿性自身免疫性糖尿病[LADA]），288例1型糖尿病患者和359例正常受试者。代谢综合征的频率在1型糖尿病患者（31.9%）和LADA患者（41.9%）中有显著差异（P = 0.015），并且在这两种情况下的频率低于2型糖尿病患者（88.8%）（P < 0.0001）。排除葡萄糖作为变量，代谢综合征的患病率在自身免疫性糖尿病（1型糖尿病和/或LADA）患者（17.3%）和对照受试者（23.7%）中相似，但在2型糖尿病患者（47.8%）中仍然更常见（所有组P = 0.001）。在1型糖尿病患者和LADA患者中，代谢综合征的各个组成部分相似，但比2型糖尿病患者更不常见（均P < 0.0001）。结论：2型糖尿病患者的代谢综合征患病率明显高于LADA患者或1型糖尿病成人患者。排除葡萄糖作为变量，代谢综合征在自身免疫性糖尿病患者中并不比对照组更普遍。代谢综合征不是自身免疫性糖尿病的特征。
OBJECTIVE—The purpose of this study was to estimate whether prevalence of metabolic syndrome in adult European diabetic patients is associated with type of diabetes. RESEARCH DESIGN AND METHODS—A consecutive series of patients attending hospital-based diabetes clinics were assessed for the frequency of metabolic syndrome and compared with population-based control subjects as part of the Action LADA study. In total, 2,011 subjects (aged 30–70 years) were studied, including 1,247 patients with recent-onset type 2 diabetes without glutamic acid decarboxylase autoantibodies (GADAs), 117 non–insulin-requiring patients with GADAs who had not received insulin therapy for at least 6 months after diagnosis (designated latent autoimmune diabetes of adults [LADA]), 288 type 1 diabetic patients, and 359 normal subjects. RESULTS—Frequency of metabolic syndrome was significantly different in patients with type 1 diabetes (31.9%) and LADA (41.9%) (P = 0.015) and in both conditions was less frequent than in type 2 diabetic patients (88.8%) (P < 0.0001 for each). Eliminating glucose as a variable, the prevalence of metabolic syndrome was similar in patients with autoimmune diabetes (type 1 diabetes and/or LADA) (17.3%) and control subjects (23.7%) but remained more common in type 2 diabetic patients (47.8%) (P = 0.001 for all groups). In both type 1 diabetic patients and those with LADA, individual components of metabolic syndrome were similar but less common than in type 2 diabetic patients (P < 0.0001 for each). CONCLUSIONS—The prevalence of metabolic syndrome is significantly higher in type 2 diabetic patients than in patients with LADA or adults with type 1 diabetes. Excluding glucose as a variable, metabolic syndrome is not more prevalent in patients with autoimmune diabetes than in control subjects. Metabolic syndrome is not a characteristic of autoimmune diabetes.
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