EFFECT OF TRITON ON LIPOPROTEIN LIPASE OF RAT PLASMA
EFFECT OF TRITON ON LIPOPROTEIN LIPASE OF RAT PLASMA
复制标题
DOI：
10.1152/ajplegacy.1957.188.2.399
复制
发表时间：
1957-01-01
影响因子：
--
通讯作者：
PAGE, IH
中科院分区：
文献类型：
--
作者：
SCHOTZ, MC;SCANU, A;PAGE, IH
当肝素后血浆与椰子油底物孵育时，光密度降低，未酯化脂肪酸增加。通过先前对大鼠静脉注射Triton防止未酯化酸的增加。向含有肝素后血浆和椰子油乳液的系统中添加Triton后血浆可抑制脂蛋白脂肪酶活性。在加入肝素后血浆之前，Triton与椰子油底物孵育可抑制脂蛋白脂肪酶活性。它的结论是抑制脂蛋白脂肪酶活性的Triton是由于修改的基板，使酶不能再行动。此外，它是建议的主要原因是Triton涂层的血浆脂蛋白，导致其错误的catalysts。
When postheparin plasma was incubated with a coconut oil substrate, a decrease in optical density and an increase in unesterified fatty acids occurred. The increase in un-esterified acids was prevented by previous intravenous injection of Triton to rats. Addition of post-Triton plasma to a system containing postheparin plasma and coconut oil emulsion inhibited the lipoprotein lipase activity. Incubation of Triton with coconut oil substrate before addition of postheparin plasma caused inhibition of lipoprotein lipase activity. It is concluded that inhibition of lipoprotein lipase activity by Triton is due to modification of the substrate such that the enzyme can no longer act. Further, it is suggested that the chief cause of Triton hyperlipemia is coating of the plasma lipoproteins by Triton resulting in their faulty catabolism.