Blimp-1 Transcription Factor Is Required for the Differentiation of Effector CD8+ T Cells and Memory Responses
Blimp-1 Transcription Factor Is Required for the Differentiation of Effector CD8+ T Cells and Memory Responses
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DOI：
10.1016/j.immuni.2009.06.021
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发表时间：
2009-08-21
期刊：
影响因子：
32.4
通讯作者：
Nutt, Stephen L.
中科院分区：
文献类型：
--
作者：
Kallies, Axel;Xin, Annie;Nutt, Stephen L.
病毒感染后，初始CD 8（+）T细胞增殖并分化为细胞毒性和产生嘌呤的效应细胞。在这里，我们发现转录因子Blimp-1是浆细胞分化的关键调节因子，是CD 8（+）T细胞分化为功能性杀伤T细胞以应对流感病毒所必需的。Blimp-1对于记忆T细胞的产生并不重要，但对于它们在再感染时的有效回忆反应至关重要。抗原特异性Blimp-1缺陷型CD 8（+）T细胞未能适当调节杀伤T细胞应答所必需的转录程序，并显示出向感染部位的迁移受损。本研究确定Blimp-1是CD 8（+）效应T细胞终末分化的主要调节因子，并揭示了调节T和B细胞终末分化的途径的保守性。
In response to viral infection, naive CD8(+) T cells proliferate and differentiate into cytotoxic and cytokine-producing effector cells. Here we showed that the transcription factor Blimp-1, a crucial regulator of plasma cell differentiation, was required for CD8(+) T cells to differentiate into functional killer T cells in response to influenza virus. Blimp-1 was not essential for the generation of memory T cells but was crucial for their efficient recall response upon reinfection. Antigen-specific Blimp-1-deficient CD8(+) T cells failed to appropriately regulate the transcriptional program essential for killer T cell responses and showed impaired migration to the site of infection. This study identifies Blimp-1 as a master regulator of the terminal differentiation of CD8(+) effector T cells and uncovers a conservation of the pathways that regulate the terminal differentiation of T and B cells.