Influence of pores created by laser superfinishing on osseointegration of titanium alloy implants.
Influence of pores created by laser superfinishing on osseointegration of titanium alloy implants.
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DOI：
10.1002/jbm.a.30013
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发表时间：
2004-06
期刊：
影响因子：
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通讯作者：
R. Stangl;A. Pries;B. Loos;M. Müller;R. Erben
中科院分区：
文献类型：
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作者：
R. Stangl;A. Pries;B. Loos;M. Müller;R. Erben
本研究的目的是在兔髓内模型中评估孔径为25、50和200 μ m的铜蒸气激光-超精钛合金（Ti6 Al 4V）植入物的骨整合。对照种植体采用喷砂法制备。每只动物的股骨和肱骨均接受了所有四种不同的植入物。使用静态和动态组织形态计量学，骨-种植体界面和种植体周围骨组织进行了检查后3，6，12周植入。在激光超精加工种植体中，25微米孔径的总骨-种植体接触最小，50和200微米孔径在所有时间点相似。然而，在骨-植入物接触方面，所有激光超精加工表面均劣于刚玉喷砂（CB）对照植入物。在12周的研究期内，最初在孔隙内形成的编织骨的重塑仅发生在具有200微米孔隙的植入物中。在所有时间点，具有25微米孔的种植体显示出最高量的种植体周围骨体积，表明种植体周围骨的量与骨-种植体界面的质量无关。在术后3周和6周，我们没有发现不同种植体表面之间的矿物质沉积率或骨形成率存在任何差异。然而，试验结束时，与CB种植体相比，50和200微米孔种植体的种植体周围骨形成率分别高出70%和62%。我们的结论是，尽管激光超精加工种植体在骨整合方面并不上级于CB对照种植体，但我们的研究为各种尺寸的孔内骨重建的机制提供了进一步的见解，并可能为未来的实验提供基础，以设计最佳的种植体表面与现代激光技术的帮助。
The aim of this study was to assess the osseointegration of copper vapor laser-superfinished titanium alloy (Ti6Al4V) implants with pore sizes of 25, 50, and 200 microm in a rabbit intramedullary model. Control implants were prepared by corundum blasting. Each animal received all four different implants in both femora and humeri. Using static and dynamic histomorphometry, the bone-implant interface and the peri-implant bone tissue were examined 3, 6, and 12 weeks postimplantation. Among the laser-superfinished implants, total bone-implant contact was smallest for the 25-microm pores, and was similar for 50- and 200-microm pore sizes at all time points. However, all laser-superfinished surfaces were inferior to corundum-blasted (CB) control implants in terms of bone-implant contact. Within the 12-week study period, remodeling of woven bone initially formed within pores occurred only in the implants with 200-microm pores. Implants with 25-microm pores showed the highest amount of peri-implant bone volume at all time points, indicating that the amount of peri-implant bone was not correlated with the quality of the bone-implant interface. At 3 and 6 weeks postsurgery, we did not find any differences in mineral apposition rates or bone formation rates between the various implant surfaces. However, the peri-implant bone formation rate at the end of the trial was 70 and 62% higher in implants with 50- and 200-microm pores compared with CB implants, respectively. We conclude that, although laser-superfinished implants were not superior to CB control implants in terms of osseointegration, our study has provided further insights into the mechanisms of bone remodeling within pores of various sizes, and may form a basis for future experiments to design optimal implant surfaces with the help of modern laser technology.