A unique autopsy case of ascending aortic dissection caused by giant cell arteritis without drug therapy
A unique autopsy case of ascending aortic dissection caused by giant cell arteritis without drug therapy
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巨细胞动脉炎未经药物治疗导致升主动脉夹层尸检独特案例
DOI：
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发表时间：
2019
期刊：
影响因子：
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通讯作者：
S. Aishima
中科院分区：
文献类型：
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作者：
Yukari Takase;Y. Murakami;Jumpei Nishi;O. Tokunaga;Toshiharu Matsumoto;S. Aishima
巨细胞动脉炎是大中型动脉的肉芽肿性炎症，主要发生在老年女性中。在该病例中，一名76岁女性因C反应蛋白（CRP）水平高而住院检查，但胸腹部计算机断层扫描（CT）或头部磁共振成像（MRI）未发现任何异常。在第一次访视后的第46天，她因心脏压塞突然死亡。经病理解剖，我们发现死因是升主动脉发生巨细胞动脉炎所致的急性主动脉夹层（斯坦福大学A型）。组织学上，巨细胞肉芽肿性血管炎见于升主动脉、胸降主动脉和腹主动脉及其分支。有趣的是，类似的肉芽肿性血管炎也见于其他多个器官的中小血管，包括心脏、肝脏、子宫体及其附件。据我们所知，巨细胞动脉炎伴多器官肉芽肿性改变以前未见报道。我们在此报告一个独特的巨细胞动脉炎的尸检病例，病人没有接受药物治疗。
Giant cell arteritis is a granulomatous inflammation of large and medium‐sized arteries, occurring predominantly in older women. In this case, a 76‐year‐old woman was hospitalized for examination because of a high C‐reactive protein (CRP) level, but nothing remarkable was found on thoracicoabdominal computed tomography (CT) or head magnetic resonanse imaging (MRI). On the 46th day from the first visit, she died suddenly due to cardiac tamponade. On pathological autopsy, we found the cause of death to be acute aortic dissection (Stanford type A) due to giant cell arteritis occurred in the ascending aorta. Histologically, granulomatous vasculitis with giant cells was recognized in the ascending aorta, thoracic descending aorta and abdominal aorta and their branches. Interestingly, similar granulomatous vasculitis was also found in the medium and small vessels of other plural organs, including the heart, liver, uterine corpus, and its appendages. To our knowledge, giant cell arteritis with multiple‐organ granulomatous changes has not been reported before. We herein reported a unique autopsy case of giant cell arteritis in a patient not treated with medication.
影响因子：
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作者：
Jennette, J. C.;Falk, R. J.;Watts, R. A.
通讯作者：
Watts, R. A.