Phycocyanin prevents hypertension and low serum adiponectin level in a rat model of metabolic syndrome
Phycocyanin prevents hypertension and low serum adiponectin level in a rat model of metabolic syndrome
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DOI：
10.1016/j.nutres.2013.03.006
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发表时间：
2013-05-01
影响因子：
4.5
通讯作者：
Omagari, Katsuhisa
中科院分区：
文献类型：
--
作者：
Ichimura, Mayuko;Kato, Shigeko;Omagari, Katsuhisa
内皮功能障碍与高血压、动脉粥样硬化和代谢综合征相关。藻蓝蛋白是在蓝绿藻螺旋藻中发现的一种色素，具有抗高血压作用。在这项研究中，我们假设螺旋藻中的藻蓝蛋白通过改善代谢综合征中的内皮功能障碍而发挥抗高血压作用。将自发性高血压/NIH 肥胖 (SHR/NDmcr-cp) 大鼠分为 4 组，然后用含或不含藻蓝蛋白的正常饮食（2500、5000 或 10 000 mg/kg 饮食）喂养 25 周。 34周龄时，尽管各组之间的收缩压没有显着差异，但喂食藻蓝蛋白的组表现出剂量依赖性的血压下降。饲喂含有藻蓝蛋白的饲料的大鼠的血清脂联素水平以及脂联素和CCAAT/增强子结合蛋白a的信使RNA水平往往高于饲喂正常饲料的大鼠，但差异无统计学意义。免疫组织化学分析显示，脂联素受体的下游靶标主动脉内皮一氧化氮合酶（eNOS）表达水平与血清脂联素水平之间存在显着的正相关性，尽管各组间eNOS表达没有显着差异。 eNOS 表达水平与收缩压之间也没有显着相关性。这些结果表明，长期服用藻蓝蛋白可以通过增强脂联素刺激的主动脉中 eNOS 的表达来改善全身血压。藻蓝蛋白可能有益于预防代谢综合征中与内皮功能障碍相关的疾病。 (C) 2013 Elsevier Inc. 保留所有权利。
Endothelial dysfunction is associated with hypertension, atherosclerosis, and metabolic syndrome. Phycocyanin is a pigment found in the blue-green algae, Spirulina, which possesses antihypertensive effect. In this study, we hypothesized that phycocyanin derived from Spirulina exerts antihypertensive actions by improving endothelial dysfunction in metabolic syndrome. Spontaneously hypertensive/NIH-corpulent (SHR/NDmcr-cp) rats were divided into 4 groups then fed a normal diet with or without phycocyanin (2500-, 5000-, or 10 000-mg/kg diet) for 25 weeks. At 34 weeks of age, although systolic blood pressure was not significantly different among groups, phycocyanin-fed groups exhibited a dose-dependent decrease in blood pressure. Serum levels of adiponectin and messenger RNA levels of adiponectin and CCAAT/enhancer-binding protein a in the adipose tissue of rats fed diets containing phycocyanin tended to be higher than those of rats fed a normal diet, but the differences were not statistically significant. Immunohistochemistry analysis showed a significant and positive correlation between aortic endothelial nitric oxide synthase (eNOS) expression levels, a downstream target of the adiponectin receptor, and serum adiponectin levels, although there were no significant differences in eNOS expression among groups. There was also no significant correlation between eNOS expression levels and systolic blood pressure. These results suggest that long-term administration of phycocyanin may ameliorate systemic blood pressure by enhancing eNOS expression in aorta that is stimulated by adiponectin. Phycocyanin may be beneficial for preventing endothelial dysfunction-related diseases in metabolic syndrome. (C) 2013 Elsevier Inc. All rights reserved.