Development of type 2 diabetes in women with comorbid gestational diabetes and common mental disorders in the Born in Bradford cohort.
Development of type 2 diabetes in women with comorbid gestational diabetes and common mental disorders in the Born in Bradford cohort.
复制标题
患有妊娠糖尿病的妇女的2型糖尿病的发育和布拉德福德同龄人的常见精神障碍的发展。
DOI：
10.1136/bmjopen-2021-051498
复制
发表时间：
2022-03-14
期刊：
影响因子：
2.9
通讯作者：
Ismail K
中科院分区：
文献类型：
--
作者：
Wilson CA;Santorelli G;Reynolds RM;Simonoff E;Howard LM;Ismail K
在妊娠期糖尿病（GDM）女性人群中，比较妊娠期间有和无常见精神障碍（CMD）（抑郁和/或焦虑）的女性诊断为2型糖尿病的时间。在英国布拉德福德出生的布拉德福德队列的前瞻性研究。在2007年至2010年期间，909名女性被诊断患有GDM，与2017年之前的初级保健记录有关。暴露人群是在初级保健记录中妊娠期间有CMD指标的妇女。未暴露的是那些没有指示剂的。初级保健记录中的诊断所指示的2型糖尿病诊断时间。使用考克斯回归进行事件发生时间分析。使用链式方程进行多重插补以处理缺失数据。模型调整了母亲的年龄，种族，教育，怀孕前CMD和吸烟在怀孕期间。在大约10年的随访期间，165名女性（18%）被诊断患有2型糖尿病。没有证据表明产前CMD对GDM后发生2型糖尿病有影响（校正HR 0.95; 95% CI 0.57 - 1.57）。患有CMD的女性在GDM后患2型糖尿病的风险并没有增加。这对患有这些合并症的女性来说是令人放心的，但需要在其他研究人群中复制。
To compare, in a population of women with gestational diabetes mellitus (GDM), the time to diagnosis of Type 2 diabetes in those with and without common mental disorder (CMD) (depression and/or anxiety) during pregnancy. prospective study of the Born in Bradford cohort in Bradford, UK. 909 women diagnosed with GDM between 2007 and 2010, with linkage to their primary care records until 2017. The exposed population were women with an indicator of CMD during pregnancy in primary care records. The unexposed were those without an indicator. Time to diagnosis of type 2 diabetes as indicated by a diagnosis in primary care records. time to event analysis using Cox regression was employed. Multiple imputation by chained equations was implemented to handle missing data. Models were adjusted for maternal age, ethnicity, education, preconception CMD and tobacco smoking during pregnancy. 165 women (18%) were diagnosed with type 2 diabetes over a follow-up period of around 10 years. There was no evidence of an effect of antenatal CMD on the development of type 2 diabetes following GDM (adjusted HR 0.95; 95% CI 0.57 to 1.57). Women with CMD were not at an increased risk of type 2 diabetes following GDM. This is reassuring for women with these co-morbidities but requires replication in other study populations.
登录
查看更多内容
影响因子：
3.7
作者：
Bellou V;Belbasis L;Tzoulaki I;Evangelou E
通讯作者：
Evangelou E
影响因子：
7.7
作者：
Allalou A;Nalla A;Prentice KJ;Liu Y;Zhang M;Dai FF;Ning X;Osborne LR;Cox BJ;Gunderson EP;Wheeler MB
通讯作者：
Wheeler MB
DOI：
10.1111/1471-0528.12059
发表时间：
2013-02-01
影响因子：
5.8
作者：
Howard, L. M.;Bekele, D.;Marteau, T. M.
通讯作者：
Marteau, T. M.
影响因子：
4.9
作者：
Bogaerts, A. F. L.;Devlieger, R.;van den Bergh, B. R. H.
通讯作者：
van den Bergh, B. R. H.
影响因子：
6.9
作者：
Bhui, K;Bhugra, D;Desai, M
通讯作者：
Desai, M